Aims To develop and validate a non-invasive method for measuring myocardial iron in
order to allow diagnosis and treatment before overt cardiomyopathy and failure develops. …

… patients scheduled for splenectomy need to be inoculated 3 to 6 weeks prior to elective
surgery with pneumococcal, meningococcal, and Haemophilus influenzae b vaccines. Penicillin …

Heart failure from iron overload causes 71% of deaths in thalassaemia major, yet reversal of
siderotic cardiomyopathy has been reported. In order to determine the changes in …

… B Wonke and JM Walker managed the patients in clinics, set up the databases, co-designed
the study, and did the research investigations. L Anderson co-designed the study, did the …

Most deaths in beta-thalassemia major result from cardiac complications due to iron
overload. Differential effects on myocardial siderosis may exist between different chelators. A …

… Series of images showing myocardial T2* acquisition with the multiecho (a) and standard
acquisition (b) methods. The myocardial borders are more clearly identified and misregistration …

Clinical complications of transfusional iron overload are still common in patients with
thalassaemia major (TM) and it is not clear how best to monitor body iron stores during long‐term …

We have previously shown a high incidence of osteopenia and osteoporosis in patients with
thalassaemia major. These bone changes, were more severe in males than females, in …

Objectives To examine the pregnancies, mode of delivery and outcomes, review the literature
on fertility and discuss preconceptual guidance for women with β thalassaemia major. …

Fifty-one transfusion-dependent iron-loaded adult patients (38 with thalassemia major)
were treated with the orally active iron chelator deferiprone (1,2 dimethyl-3-hydroxypyrid-4-one, …