The fruit fly Drosophila melanogaster is a versatile model organism that has been used in
biomedical research for over a century to study a broad range of phenomena. There are many …

Background The best-known cause of intolerance to fluoropyrimidines is dihydropyrimidine
dehydrogenase (DPD) deficiency, which can result from deleterious polymorphisms in the …

The Drosophila Groucho (Gro) protein was the founding member of the family of transcriptional
co-repressor proteins that now includes the transducin-like enhancer of split (TLE) and …

Background: the xanthophylls lutein (L) and zeaxanthin (Z) exist in relatively high concentration
in multiple central nervous tissues (eg cortex and neural retina). L + Z in macula (ie …

The Groucho (Gro)/TLE/Grg family of corepressors operates in many signaling pathways (including
Notch and Wnt). Gro/TLE proteins recognize a wide range of transcriptional …

The 8p11 myeloproliferative syndrome is a rare, aggressive condition associated with
reciprocal translocations of chromosome band 8p11, most commonly the t(8;13)(p11;q12). To …

Similar retinitis pigmentosa (RP) phenotypes can result from mutations affecting different
rhodopsin regions, and distinct amino acid substitutions can cause different RP severity and …

OBJECTIVE: Hyperhomocysteinaemia is associated with peripheral arterial disease (PAD).
There are inter-individual variations in the metabolism of homocysteine because of genetic …

Background We investigated sera from elderly subjects with and without age-related
macular degeneration (AMD) for presence of autoantibodies (AAbs) against human macular …

Objective A cholesteatoma is a mass of keratinising epithelium in the middle ear. It is a rare
disorder that is associated with significant morbidity, and its causative risk factors are poorly …