Shared decision making enables a clinician and patient to participate jointly in making a
health decision, having discussed the options and their benefits and harms, and having …

Background & Aims All oral direct acting antivirals (DAAs) effectively treat chronic hepatitis C
virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared …

Background & Aims Direct-acting antivirals have become widely used for patients with
chronic hepatitis C virus infection with decompensated cirrhosis. Virological responses are …

The remarkable success of SARS CoV-2 mRNA-based vaccines and the ensuing interest in
mRNA vaccines and therapeutics have highlighted the need for a scalable clinical-enabling …

Background This study aimed to explore the beliefs of people with knee osteoarthritis (OA)
about the disease, and how these beliefs had formed and what impact these beliefs had on …

Ultra-high angular resolution in astronomy has always been an important vehicle for making
fundamental discoveries. Recent results in direct imaging of the vicinity of the supermassive …

PURPOSE An informed decision to accept a health care intervention requires an understanding
of its likely benefit. This study assessed participants' estimates of the benefit, as well as …

Solutions to the Traveling Salesperson Problem (TSP) have practical applications to processes
in transportation, logistics, and automation, yet must be computed with minimal delay to …

Background and objectives Patients with decompensated cirrhosis rarely receive palliative
and supportive care interventions, which are routine in other life-limiting diseases. We aimed …

Palliative care remains suboptimal in advanced cirrhosis, in part relating to a lack of
evidence-based interventions. Ascites remains the most common cirrhosis complication resulting in …