Background The Four-Dimensional Symptom Questionnaire (4DSQ) is a self-report questionnaire
that has been developed in primary care to distinguish non-specific general distress …

Background Medically unexplained physical symptoms (MUPS) are physical symptoms for
which no adequate medical explanation can be found after proper examination. The …

We define the minimal important change (MIC) as a threshold for a minimal within-person
change over time above which patients perceive themselves importantly changed. There is a …

In non-clinical (working) populations it is important to differentiate between general distress,
on the one hand, and psychiatric symptoms—depression, anxiety and somatization—on the …

The aim of this study was to validate the Dutch version of the Kessler-10 (K10) as well as an
extended version (EK10) in screening for depressive and anxiety disorders in primary care. …

Background The network approach to psychopathology conceives mental disorders as sets
of symptoms causally impacting on each other. The strengths of the connections between …

Objective The Barthel index (BI) is a widely used observer-based instrument to measure
physical function. Our objective is to assess the structural validity, reliability, and interpretability …

Objective Central sensitization (CS), a mechanism explaining the persistence of symptoms,
has been the focus of many research projects. Explanations given to patients with chronic …

Objectives To evaluate the effectiveness of a participatory workplace intervention compared
with usual care for sick-listed employees with distress, with regard to return to work (RTW) …

Background To date, mental health problems and mental workload have been increasingly
related to long-term sick leave and disability. However, there is, as yet, no structured protocol …