By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Background Type 1 diabetes is typically considered a disease of children and young adults.
Genetic susceptibility to young-onset type 1 diabetes is well defined and does not …

Background Research using data-driven cluster analysis has proposed five subgroups of
diabetes with differences in diabetes progression and risk of complications. We aimed to …

Importance Glycemic targets in diabetes have been developed to minimize complication risk.
Patients with heterozygous, inactivating glucokinase (GCK)mutations have mild fasting …

Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood 1 . Previous genome-…

Aims/hypothesis Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency.
Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/…

OBJECTIVE—Neonatal diabetes can result from mutations in the Kir6.2 or sulfonylurea
receptor 1 (SUR1) subunits of the ATP-sensitive K + channel. Transfer from insulin to oral …

To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide
association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and …