Preeclampsia is a disease of pregnancy classically defined by the development of new-onset
hypertension and proteinuria. Serous retinal detachment is a rare complication of severe …

Background General Practice Co-Operatives provide most out of hours care in communities
in Ireland. Limited data exists on patient complaints. This study reports on complaints at …

Background End-of-life planning means decision making with patients, formulating and
recording decisions regarding their end-of-life care. Although clearly linked with benefits …

Background: Hyponatremia and hypernatremia, as conventionally defined (< 135 mEq/L and>
145 mEq/L, respectively), are associated with increased perioperative morbidity and …

Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …

The absorption of orally administered drug products is a complex, dynamic process, dependant
on a range of biopharmaceutical properties; notably the aqueous solubility of a molecule…

Despite countless advances in recent decades across various in vitro, in vivo and in silico
tools, anticipation of whether a drug will show a human food effect (FE) remains challenging. …

Novel formulations that overcome the solubility limitations of poorly water soluble drugs (PWSD)
are becoming ever more critical to a drug development process inundated with these …

Increasing numbers of poorly water soluble drugs in development has intensified need for
bio-enabling formulations including Lipid-Based Formulations (LBF) and Solid Dispersions (…

Obsidian, originating from the Rocky Mountains and the West, was an exotic exchange
commodity in Eastern North America that was often deposited in elaborate caches and burials …