Importance Systematic reviews of diagnostic test accuracy synthesize data from primary
diagnostic studies that have evaluated the accuracy of 1 or more index tests against a reference …

Systematic reviews of diagnostic test accuracy (DTA) studies are fundamental to the decision
making process in evidence based medicine. Although such studies are regarded as high …

When applying study results to their practice, the clinician is constrained by a number of
factors, perhaps none more important than spectrum bias, which describes the effect a change …

An important question for clinicians appraising a meta‐analysis is: are the findings likely to
be valid in their own practice—does the reported effect accurately represent the effect that …

Background Our knowledge of the incidence and prevalence of inflammatory bowel disease
(IBD) is uncertain. Recent studies reported an increase in prevalence. However, they …

Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes
mellitus (T2DM) and a prior cardiovascular disease (CVD) event. Objectives: To establish …

For many users of the biomedical literature, abstracts may be the only source of information
about a study. Hence, abstracts should allow readers to evaluate the objectives, key design …

Background Over the last decade there have been a number of guidelines published, aimed
at improving the quality of reporting in published studies and reviews. In systematic reviews …

Deceased organ donation in the United Kingdom (UK) is governed by the Human Tissue Act
2004 and the Human Tissue Act (Scotland) 2006 and operates under an opt-in system of …

Aims/Hypothesis The aim of this research was to explore the relationship between incident
epilepsy and type 1 diabetes in British participants. Methods Using The Health Improvement …