Background Although heart rate and respiratory rate in children are measured routinely in
acute settings, current reference ranges are not based on evidence. We aimed to derive new …

Background Neuraminidase inhibitors (NIs) are stockpiled and recommended by public
health agencies for treating and preventing seasonal and pandemic influenza. They are used …

Background Near-patient testing has made self-monitoring of anticoagulation with warfarin
feasible, and several trials have suggested that such monitoring might be equal to or better …

Background Previous studies identified worrying levels of sphygmomanometer inaccuracy
and have not been repeated in the era of digital measurement of blood pressure Aim To …

Objectives To describe the association and its magnitude between body mass index
category, sex, and cardiovascular disease risk parameters in school aged children in highly …

Objective To describe the potential benefits and harms of oseltamivir by reviewing all clinical
study reports (or similar document when no clinical study report exists) of randomised …

Background— To date, there has been no systematic examination of the relationship between
international normalized ratio (INR) control measurements and the prediction of adverse …

Background There have been no studies of the patterns of post-marketing withdrawals of
medicinal products to which adverse reactions have been attributed. We identified medicinal …

… Carl Heneghan, senior clinical research fellow1, … Perera R, Heneghan C, Yudkin P.
Graphical method for depicting randomised trials of complex interventions. BMJ 2007;334:127-9 …

Background The diagnosis of hypertension has traditionally been based on blood-pressure
measurements in the clinic, but home and ambulatory measurements better correlate with …