User profiles for Christopher Mayne

Christopher G Mayne

Celgene
Verified email at celgene.com
Cited by 2074

Rapid parameterization of small molecules using the force field toolkit

CG Mayne, J Saam, K Schulten… - Journal of …, 2013 - Wiley Online Library
The inability to rapidly generate accurate and robust parameters for novel chemical matter
continues to severely limit the application of molecular dynamics simulations to many …

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

SW Fanning, CG Mayne, V Dharmarajan, KE Carlson… - elife, 2016 - elifesciences.org
10.7554/eLife.12792.001 Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1),
especially Y537S and D538G, have been linked to acquired resistance to endocrine …

An epidemiological study to establish the prevalence of urinary symptoms and felt need in the community: the Leicestershire MRC Incontinence Study

…, N Smith, M Clarke, C Jagger, C Mayne… - Journal of Public …, 2000 - academic.oup.com
Background.The aim of the study was to establish the prevalence of urinary symptoms and
felt the need in adults. This paper discusses problems with setting thresholds to distinguish …

1,25‐Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis

CG Mayne, JA Spanier, LM Relland… - European journal of …, 2011 - Wiley Online Library
Multiple sclerosis (MS) is an incurable autoimmune neurodegenerative disease.
Environmental factors may be key to MS prevention and treatment. MS prevalence and severity …

Induced and natural regulatory T cells in the development of inflammatory bowel disease

CG Mayne, CB Williams - Inflammatory bowel diseases, 2013 - academic.oup.com
The mucosal immune system mediates contact between the host and the trillions of microbes
that symbiotically colonize the gastrointestinal tract. Failure to tolerate the antigens within …

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

JA Katzenellenbogen, CG Mayne… - Nature Reviews …, 2018 - nature.com
Oestrogen receptor-α (ERα), a key driver of breast cancer, normally requires oestrogen for
activation. Mutations that constitutively activate ERα without the need for hormone binding are …

Botulinum toxin a versus placebo for refractory detrusor overactivity in women: a randomised blinded placebo-controlled trial of 240 women (the RELAX study)

DG Tincello, S Kenyon, KR Abrams, C Mayne… - European urology, 2012 - Elsevier
BACKGROUND: Emerging data suggest botulinum toxin is an effective treatment for detrusor
overactivity (DO), but large studies confirming efficacy and safety are lacking. OBJECTIVE: …

Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)

TW Moore, CG Mayne… - Molecular …, 2010 - academic.oup.com
Because of their central importance in gene regulation and mediating the actions of many
hormones, the nuclear receptors (NRs) have long been recognized as very important …

Uterine prolapse

A Doshani, REC Teo, CJ Mayne, DG Tincello - Bmj, 2007 - bmj.com
Uterine prolapse is the herniation of the uterus into or beyond the vagina as a result of failure
of the ligamentous and fascial supports. It often coexists with prolapse of the vaginal walls, …

Adaptive multilevel splitting method for molecular dynamics calculation of benzamidine-trypsin dissociation time

I Teo, CG Mayne, K Schulten… - Journal of chemical theory …, 2016 - ACS Publications
Adaptive multilevel splitting (AMS) is a rare event sampling method that requires minimal
parameter tuning and allows unbiased sampling of transition pathways of a given rare event. …