User profiles for Christopher Mayne
Christopher G MayneCelgene Verified email at celgene.com Cited by 2074 |
Rapid parameterization of small molecules using the force field toolkit
CG Mayne, J Saam, K Schulten… - Journal of …, 2013 - Wiley Online Library
The inability to rapidly generate accurate and robust parameters for novel chemical matter
continues to severely limit the application of molecular dynamics simulations to many …
continues to severely limit the application of molecular dynamics simulations to many …
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation
10.7554/eLife.12792.001 Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1),
especially Y537S and D538G, have been linked to acquired resistance to endocrine …
especially Y537S and D538G, have been linked to acquired resistance to endocrine …
An epidemiological study to establish the prevalence of urinary symptoms and felt need in the community: the Leicestershire MRC Incontinence Study
…, N Smith, M Clarke, C Jagger, C Mayne… - Journal of Public …, 2000 - academic.oup.com
Background.The aim of the study was to establish the prevalence of urinary symptoms and
felt the need in adults. This paper discusses problems with setting thresholds to distinguish …
felt the need in adults. This paper discusses problems with setting thresholds to distinguish …
1,25‐Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis
CG Mayne, JA Spanier, LM Relland… - European journal of …, 2011 - Wiley Online Library
Multiple sclerosis (MS) is an incurable autoimmune neurodegenerative disease.
Environmental factors may be key to MS prevention and treatment. MS prevalence and severity …
Environmental factors may be key to MS prevention and treatment. MS prevalence and severity …
Induced and natural regulatory T cells in the development of inflammatory bowel disease
CG Mayne, CB Williams - Inflammatory bowel diseases, 2013 - academic.oup.com
The mucosal immune system mediates contact between the host and the trillions of microbes
that symbiotically colonize the gastrointestinal tract. Failure to tolerate the antigens within …
that symbiotically colonize the gastrointestinal tract. Failure to tolerate the antigens within …
Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance
JA Katzenellenbogen, CG Mayne… - Nature Reviews …, 2018 - nature.com
Oestrogen receptor-α (ERα), a key driver of breast cancer, normally requires oestrogen for
activation. Mutations that constitutively activate ERα without the need for hormone binding are …
activation. Mutations that constitutively activate ERα without the need for hormone binding are …
Botulinum toxin a versus placebo for refractory detrusor overactivity in women: a randomised blinded placebo-controlled trial of 240 women (the RELAX study)
BACKGROUND: Emerging data suggest botulinum toxin is an effective treatment for detrusor
overactivity (DO), but large studies confirming efficacy and safety are lacking. OBJECTIVE: …
overactivity (DO), but large studies confirming efficacy and safety are lacking. OBJECTIVE: …
Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)
Because of their central importance in gene regulation and mediating the actions of many
hormones, the nuclear receptors (NRs) have long been recognized as very important …
hormones, the nuclear receptors (NRs) have long been recognized as very important …
Uterine prolapse
A Doshani, REC Teo, CJ Mayne, DG Tincello - Bmj, 2007 - bmj.com
Uterine prolapse is the herniation of the uterus into or beyond the vagina as a result of failure
of the ligamentous and fascial supports. It often coexists with prolapse of the vaginal walls, …
of the ligamentous and fascial supports. It often coexists with prolapse of the vaginal walls, …
Adaptive multilevel splitting method for molecular dynamics calculation of benzamidine-trypsin dissociation time
I Teo, CG Mayne, K Schulten… - Journal of chemical theory …, 2016 - ACS Publications
Adaptive multilevel splitting (AMS) is a rare event sampling method that requires minimal
parameter tuning and allows unbiased sampling of transition pathways of a given rare event. …
parameter tuning and allows unbiased sampling of transition pathways of a given rare event. …