VIP: molecular biology and neurobiological function

I Gozes, DE Brenneman - Molecular neurobiology, 1989 - Springer
In the mammalian brain, a major regulatory peptide is vasoactive intestinal peptide (VIP).
This 28 amino acid peptide, originally isolated from the porcine duodenum, was later found in …

Neuroprotection: a comparative view of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide

DE Brenneman - Peptides, 2007 - Elsevier
The neuroprotective properties of vasoactive intestinal peptide (VIP) and pituitary adenylate
cyclase-activating polypeptide (PACAP) place these peptides in a special category of …

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

DE Brenneman, GL Westbrook, SP Fitzgerald… - Nature, 1988 - nature.com
The clinical manifestations of AIDS (acquired immune deficiency syndrome) often include
neuropsychiatric and neurological deficits 1–4 , including early memory loss and progressive …

Complete sequence of a novel protein containing a femtomolar‐activity‐dependent neuroprotective peptide

…, G Gibney, G Glazner, DE Brenneman… - Journal of …, 1999 - Wiley Online Library
: The vulnerability of neurons and the irreversibility of loss make discoveries of neuroprotective
compounds fundamentally important. Here, the complete coding sequence of a novel …

From vasoactive intestinal peptide (VIP) through activity-dependent neuroprotective protein (ADNP) to NAP: a view of neuroprotection and cell division

…, I Divinsky, I Pilzer, M Fridkin, DE Brenneman… - Journal of Molecular …, 2003 - Springer
Accelerated neuronal death brings about cognitive as well as motor and other dysfunctions.
A major neuropeptide, vasoactive intestinal peptide (VIP), has been shown to be …

[HTML][HTML] Cloning and characterization of the human activity-dependent neuroprotective protein

…, Y Wollman, HJ Eyre, JC Mulley, DE Brenneman… - Journal of Biological …, 2001 - ASBMB
We have recently cloned the mouse activity-dependent neuroprotective protein (ADNP).
Here, we disclose the cloning of human ADNP (hADNP) from a fetal brain cDNA library. …

Activity-dependent neuroprotective protein: a novel gene essential for brain formation

…, AM Goldsweig, SJ Servoss, DE Brenneman… - Developmental Brain …, 2003 - Elsevier
We have recently cloned the novel homeobox-containing activity-dependent neuroprotective
protein (ADNP). In the current study, mouse ADNP was shown to be expressed at the time …

Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis

…, RR Lincoln, PA Gourraud, D Brenneman… - Annals of …, 2012 - Wiley Online Library
Objective: We sought to determine whether vitamin D status is associated with developing
new T2 lesions or contrast‐enhancing lesions on brain magnetic resonance imaging (MRI) in …

Growth factor function of vasoactive intestinal peptide in whole cultured mouse embryos

P Gressens, JM Hill, I Gozes, M Fridkin, DE Brenneman - Nature, 1993 - nature.com
FACTORS controlling central nervous system (CNS) growth immediately after neurulation are
mostly unknown. Vasoactive intestinal peptide (VIP) receptors are widely distributed in the …

A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice

…, Y Cohen, Y Assaf, RA Steingart, DE Brenneman… - … of Pharmacology and …, 2001 - ASPET
Brain injury induces disruption of the blood-brain barrier, edema, and release of autodestructive
factors that produce delayed neuronal damage. NAPSVIPQ (NAP), a femtomolar-acting …