Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

R Mukherjee, PJA Davies, DL Crombie, ED Bischoff… - Nature, 1997 - nature.com
… progressively hyperglycaemic and their fasting glucose levels increase up to 450 mg dl T".
Daily treatment with LG100268 (20 mg kgT") (structures shown in Fig. 2a) for 14 days not only …

Prevalence of asthma and hay fever in England and Wales.

DM Fleming, DL Crombie - Br Med J (Clin Res Ed), 1987 - bmj.com
The results concerned with the prevalence of asthma and hay fever in the large surveys of
morbidity in general practice in 1970-1 and 1981-2 were compared. In data standardised for …

Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores.

LR Hagey, DL Crombie, E Espinosa, MC Carey… - Journal of lipid …, 1993 - ASBMB
The biliary bile acid composition of gallbladder bile obtained from six species of bears (Ursidae),
the Giant panda, the Red panda, and 11 related carnivores were determined by …

Diagnostic process

DL Crombie - The Journal of the College of General Practitioners, 1963 - ncbi.nlm.nih.gov
Method This analysis was based on two groups of patients seen by the writer. The first group,
Group A, was a consecutive series of patients, 140 male and 164 female, attending for the …

CFTR mediates cAMP-and Ca2+-activated duodenal epithelial HCO3-secretion

DL Hogan, DL Crombie, JI Isenberg… - American Journal …, 1997 - journals.physiology.org
The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in duodenal
alkaline secretion has not been directly examined. The aims of this series of experiments were …

Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents

HS Ahuja, S Liu, DL Crombie, M Boehm… - Molecular …, 2001 - ASPET
… After an oral glucose challenge, plasma glucose levels increased dramatically in vehicle-treated
obese animals to more than 300 mg/dl at 30 and 60 min, compared with ∼200 mg/dl at …

Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity

…, GL Shipley, RH Eckel, N Hennuyer, DL Crombie… - Molecular …, 2001 - ASPET
… (total cholesterol level in the pool of 0.92 g/dl) and three animals that received LGD1069 (30
mg/kg/day; total cholesterol level of 1.4 g/dl). The increase in triglyceride levels in LGD1069-…

Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice

DL Hogan, DL Crombie, JI Isenberg… - …, 1997 - gastrojournal.org
BACKGROUND & AIMS: Duodenal bicarbonate secretion is an important factor in epithelial
protection. The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in …

Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes

…, CL Broderick, MA Carfagna, DL Crombie… - …, 2006 - academic.oup.com
Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione
(TZD) PPARγ agonists, such as rosiglitazone, produce insulin sensitization in rodent …

Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

…, RJ Ardecky, JH Chen, DL Crombie… - Journal of medicinal …, 2003 - ACS Publications
Previous data have shown that RXR-selective agonists (eg, 3 and 4) are insulin sensitizers
in rodent models of non-insulin-dependent diabetes mellitus (NIDDM). Unfortunately, they …