Objective To systematically review the literature and, where appropriate, meta-analyse
studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in …

… Quit rates will vary between studies depending on many factors, including the period in
which the study was done and the definition of abstinence used by the study. To provide a …

… Nicotine chewing gum is available either as a 2 mg or 4 mg preparation, and in many
countries the lower dose is sold 'over the counter' (OTC), without a prescription from a medical …

Background Acute coronary, cerebrovascular, and peripheral vascular events have common
underlying arterial pathology, risk factors, and preventive treatments, but they are rarely …

Background The incidence of stroke is predicted to rise because of the rapidly ageing
population. However, over the past two decades, findings of randomised trials have identified …

Background Although heart rate and respiratory rate in children are measured routinely in
acute settings, current reference ranges are not based on evidence. We aimed to derive new …

Objectives: To assess the accuracy in diagnosing heart failure of clinical features and
potential primary care investigations, and to perform a decision analysis to test the impact of …

… M Thompson, N Ninis, M Levin, A Harnden, R Mayon-White, R Perera, and D Mant
contributed to the design of the primary-care data analysis. N Ninis and C Phillips recruited the …

Background Valvular heart disease (VHD) is expected to become more common as the
population ages. However, current estimates of its natural history and prevalence are based on …

… We thank the many surgeons, oncologists, and general practitioners whose commitment
made this research possible. We particularly thank the women with breast cancer who …