Statistical approaches to overdispersion, correlated errors, shrinkage estimation, and
smoothing of regression relationships may be encompassed within the framework of the …

Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …

The application of Cox's (1972) regression model for censored survival data to epidemio-logical
studies of chronic disease incidence is discussed. A related model for association in …

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of
multiple genetic and environmental risk factors. We report the findings of a genome-wide …

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA)
scan 1 on seven diseases, including the multifactorial autoimmune disease type 1 …

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …

Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be
more powerful than linkage analysis if the appropriate density of polymorphic markers were …

To fully understand the allelic variation that underlies common diseases, complete genome
sequencing for many individuals with and without disease is required. This is still not …

Background Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …

Background Age-related macular degeneration is the most common cause of blindness in
Western populations. Susceptibility is influenced by age and by genetic and environmental …