Objective The commensal microbiota, host immunity and metabolism participate in a
signalling network, with diet influencing each component of this triad. In addition to diet, many …

Recent studies from this laboratory have demonstrated that angiotensin II (Ang II) stimulates
the expression of plasminogen activator inhibitor 1 (PAI-1) in cultured endothelial cells. This …

Bioactive peptides derived from milk proteins are of particular interest to the food industry
due to the potential functional and physiological roles that they demonstrate, particularly in …

Background: Although plasma total homocysteine has been identified as an independent
risk factor for vascular disease in a multitude of studies, there is a considerable overlap in …

Objectives There is growing evidence that antihypertensive agents, particularly centrally
acting ACE inhibitors (CACE-Is), which cross the blood–brain barrier, are associated with a …

Background: Centrally acting angiotensin converting enzyme inhibitors (CACE-Is) are
associated with reduced rates of cognitive decline in patients with dementia. CACE-Is may also …

With evidence for efficacy in such diverse clinical settings such as stable coronary artery
disease, reperfusion injury, and contrast-induced nephropathy, trimetazidine (TMZ) is novel …

Urokinase-type plasminogen activator (uPA) binds to cells via a specific
glycosylphosphatidylinositol-anchored receptor. Although occupancy of the uPA receptor (uPAR) …

Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary
to ensure that the prescribing competency of future doctors is of a uniform high standard. …

To test the hypothesis that urokinase-type plasminogen activator (uPA) plays an important
role in liver regeneration in vivo, partial hepatectomy was performed on wild-type and uPA-…