User profiles for David Melzer
David MelzerProfessor of Epidemiology and Public Health, University of Exeter Verified email at exeter.ac.uk Cited by 40704 |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
…, LJ McCulloch, R McPherson, C Meisinger, D Melzer… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
Systematic identification of trans eQTLs as putative drivers of known disease associations
Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …
Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults
Context Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers.
Evidence of effects in animals has generated concern over low-level chronic exposures …
Evidence of effects in animals has generated concern over low-level chronic exposures …
Vitamin D and risk of cognitive decline in elderly persons
Background To our knowledge, no prospective study has examined the association between
vitamin D and cognitive decline or dementia. Methods We determined whether low levels of …
vitamin D and cognitive decline or dementia. Methods We determined whether low levels of …
[HTML][HTML] DNA methylation-based measures of biological age: meta-analysis predicting time to death
…, S Bandinelli, DG Hernandez, D Melzer… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic
age”,“DNAm age”, have been shown to be robust biomarkers of age in humans. We …
age”,“DNAm age”, have been shown to be robust biomarkers of age in humans. We …
Preexisting comorbidities predicting COVID-19 and mortality in the UK biobank community cohort
Background Hospitalized COVID-19 patients tend to be older and frequently have
hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk …
hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk …
Social inequalities and the common mental disorders: a systematic review of the evidence
Background: Of two large-scale government-commissioned studies of common mental
disorders in the UK, one found occupational social class to be the strongest marker of risk while …
disorders in the UK, one found occupational social class to be the strongest marker of risk while …
Epigenetic signatures of cigarette smoking
…, N Sotoodehnia, SLR Kardia, D Melzer… - Circulation …, 2016 - Am Heart Assoc
Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…
[HTML][HTML] Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06
Background Bisphenol A (BPA) is a high production volume chemical widely used in food
and drinks packaging. Associations have previously been reported between urinary BPA …
and drinks packaging. Associations have previously been reported between urinary BPA …