User profiles for David Melzer

David Melzer

Professor of Epidemiology and Public Health, University of Exeter
Verified email at exeter.ac.uk
Cited by 40704

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

…, LJ McCulloch, R McPherson, C Meisinger, D Melzer… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

…, MR Jarvelin, U Sovio, AJ Bennett, D Melzer… - Science, 2007 - science.org
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …

Systematic identification of trans eQTLs as putative drivers of known disease associations

…, E Reinmaa, K Fischer, M Nelis, L Milani, D Melzer… - Nature …, 2013 - nature.com
Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …

Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults

…, WE Henley, M Depledge, RB Wallace, D Melzer - Jama, 2008 - jamanetwork.com
Context Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers.
Evidence of effects in animals has generated concern over low-level chronic exposures …

Vitamin D and risk of cognitive decline in elderly persons

…, A Cherubini, L Ferrucci, D Melzer - Archives of internal …, 2010 - jamanetwork.com
Background To our knowledge, no prospective study has examined the association between
vitamin D and cognitive decline or dementia. Methods We determined whether low levels of …

[HTML][HTML] DNA methylation-based measures of biological age: meta-analysis predicting time to death

…, S Bandinelli, DG Hernandez, D Melzer… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic
age”,“DNAm age”, have been shown to be robust biomarkers of age in humans. We …

Preexisting comorbidities predicting COVID-19 and mortality in the UK biobank community cohort

…, CL Kuo, GA Kuchel, D Melzer - The Journals of …, 2020 - academic.oup.com
Background Hospitalized COVID-19 patients tend to be older and frequently have
hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk …

Social inequalities and the common mental disorders: a systematic review of the evidence

T Fryers, D Melzer, R Jenkins - Social psychiatry and psychiatric …, 2003 - Springer
Background: Of two large-scale government-commissioned studies of common mental
disorders in the UK, one found occupational social class to be the strongest marker of risk while …

Epigenetic signatures of cigarette smoking

…, N Sotoodehnia, SLR Kardia, D Melzer… - Circulation …, 2016 - Am Heart Assoc
Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

[HTML][HTML] Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06

D Melzer, NE Rice, C Lewis, WE Henley, TS Galloway - PloS one, 2010 - journals.plos.org
Background Bisphenol A (BPA) is a high production volume chemical widely used in food
and drinks packaging. Associations have previously been reported between urinary BPA …