Estrogen receptor β (ERβ) is a novel steroid receptor that is expressed in rat prostate and
ovary. We have cloned the mouse homolog of ERβ and mapped the gene, designated Estrb, to …

Neuronal activity is an essential stimulus for induction of plasticity and normal development
of the CNS. We have used differential cloning techniques to identify a novel immediate-early …

Cytokines manifest their function through alteration of gene expression. However, target
genes for signals from cytokine receptors are largely unknown. We therefore searched for …

The otd/Otx gene family encodes paired-like homeodomain proteins that are involved in the
regulation of anterior head structure and sensory organ development. Using the yeast one-…

Laminin trimers composed of α, β, and γ chains are major components of basal laminae (BLs)
throughout the body. To date, three α chains (α1–3) have been shown to assemble into at …

The angiopoietins have recently joined the members of the vascular endothelial growth
factor family as the only known growth factors largely specific for vascular endothelium. The …

This paper describes the identification of a new family of mammalian genes that encode
secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the …

Many spontaneous, chemical-induced, and radiationinduced dominant white spotting (W)
and steel (3) mutations have been identified in the mouse. W and SI mutations have similar …

Interleukins-2 and −15 (IL-2 and IL-15) are cytokines with overlapping but distinct biological
effects. Their receptors share two subunits (the IL-2Rβ and -γ chains) that are essential for …

In Drosophila melanogaster, the frizzled gene plays an essential role in the development of
tissue polarity as assessed by the orientation of cuticular structures. Through a combination …