▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the genome…

Many metazoan gene transcripts exhibit neuron-specific splicing patterns, but the developmental
control of these splicing events is poorly understood. We show that the splicing of a …

Recent transcriptome analysis indicates that > 90% of human genes undergo alternative
splicing, underscoring the contribution of differential RNA processing to diverse proteomes in …

Two different experimental approaches have provided evidence that both U2 and Ul snRNPs
function in premRNA splicing. When the U2 snRNPs in a nuclear extract are selectively …

Understanding the biologic role of N 6 -methyladenosine (m 6 A) RNA modifications in
mRNA requires an understanding of when and where in the life of a pre-mRNA transcript the …

The Rbfox family of RNA binding proteins regulates alternative splicing of many important
neuronal transcripts, but its role in neuronal physiology is not clear 1 . We show here that …

The human genome sequence can be thought of as a picture of the human organism. However,
like an impressionist painting, the genome is a very large canvas whose details become …

Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression.
Many neuronal proteins are structurally diversified through the differential inclusion and …

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved
in multiple aspects of messenger RNA metabolism, including the repression of alternative …

Macrophages respond to inflammatory stimuli by modulating the expression of hundreds of
genes in a defined temporal cascade, with diverse transcriptional and posttranscriptional …