Objectives To assess diagnostic accuracy of screening tests for pre-diabetes and efficacy of
interventions (lifestyle or metformin) in preventing onset of type 2 diabetes in people with pre-…

Heparan sulfate proteoglycans are important constituents of the extracellular matrix and
basement membrane. Cleavage of heparan sulfate by heparanase, an endoglycosidase, is …

Objective Explore the cost-effectiveness of lifestyle interventions and metformin in reducing
subsequent incidence of type 2 diabetes, both alone and in combination with a screening …

Background Several countries, including England, have recently introduced lifestyle-focused
diabetes prevention programmes. These aim to reduce the risk of individuals with pre-…

PAGE Objective To assess the risk of adverse maternal and perinatal complications in twin
and singleton pregnancies affected by gestational diabetes mellitus (GDM), compared to the …

Background In the context of the biggest GP workforce crisis since the NHS began, the alleged
negative portrayal of UK general practice in the media is often cited as a reason for falling …

Public Health England's focus on individual behaviour change is unlikely to stem the
epidemic of type 2 diabetes

The mRNA levels of hyal‐1, hyal‐2, LUCA3 and PH20, the 4 hyaluronidases with demonstrated
endoglucosaminidase activity, were extensively profiled in normal and tumor tissues …

Background Preventing type 2 diabetes is a national priority; one aspect is the identification
and active management of ‘prediabetes’ through lifestyle change. Aim To explore what …

Objectives When seeking to prevent type 2 diabetes, a balance must be struck between
individual approaches (focusing on people’s behaviour ‘choices’) and population approaches (…