Background Most randomized trials of treatment for asthma study highly selected patients
under idealized conditions. Methods We conducted two parallel, multicenter, pragmatic trials to …

Background Patterns of health-care use and comorbidities present in patients in the period
before diagnosis of chronic obstructive pulmonary disease (COPD) are unknown. We …

OBJECTIVE. Newborn screening for cystic fibrosis remains controversial because improved
pulmonary function has not been established. Studies to date have not accounted for …

Background Newborn screening for cystic fibrosis might not be introduced if implementation
and running costs are perceived as prohibitive. Compared with clinical diagnosis, newborn …

Despite international and national guidelines, poor asthma control remains an issue. Asthma
exacerbations are costly to both the individual, and the healthcare provider. Improvements …

Bronchial hyperresponsiveness (BHR) is a key feature of asthma and may be measured by
direct methacholine challenge or indirect adenosine monophosphate (AMP) challenge. We …

Background: Intranasal corticosteroids are regarded as the first-line treatment for allergic
rhinitis, but few studies have directly compared their systemic effects. Objective: The purpose of …

OBJECTIVES: To determine whether early identification of babies with cystic fibrosis (CF)
improves outcome in the current environment of new improved treatments, considering the …

Background: Patient preference is an important factor when choosing an inhaler device for
asthma or chronic obstructive pulmonary disease (COPD). Aims: To identify characteristics of …

OBJECTIVE—Although cystic fibrosis–related diabetes (CFRD) is associated with decreased
lung function, sex is not known to influence CFRD. However, compared with male subjects …