Purpose Rearrangement of MYC occurs in a proportion of diffuse large B-cell lymphomas (DLBCL),
where they may be associated with an adverse clinical outcome. The aim of this …

Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP
to dTMP in DNA synthesis, to 5-methyltetrahydrofolate (methylTHF), the primary methyl …

To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a
genome-wide association study of two case-control series, analyzing the genotypes with …

In humans, cancer may be caused by genetics and environmental exposures; however, in the
majority of instances the identification of the critical time window of exposure is problematic…

Background Common genetic variants in immune and inflammatory response genes can
affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using …

Based on the profile of genetic alterations occurring in tumor samples from selected diffuse
large B-cell lymphoma (DLBCL) patients, 2 recent whole-exome sequencing studies …

Background Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous
subtypes. Previously, study size has limited the ability to compare and contrast the risk …

Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive
electrophiles, including metabolites of several chemotherapeutic agents, some of which are …

Using data from a genome-wide association study of 907 individuals with childhood acute
lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling …

We previously reported that 2 polymorphisms in the 5,10-methylenetetrahydrofolate reductase
(MTHFR) gene at positions C677T and A1298C were associated with lower risk of adult …