User profiles for F. Henskens
Frans HenskensConjoint Professor, School of Medicine & Public Health, University of Newcastle Verified email at newcastle.edu.au Cited by 29112 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
…, AM Hartmann, C Harvey, C Hayward, FA Henskens… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
…, V Haroutunian, AM Hartmann, FA Henskens… - The american journal of …, 2015 - cell.com
… If we sample the effect to be non-zero and again make the simplifying assumption that f đbi
j b, bĀiŪz f đbi j bi, bĀiŪ, then we can write out its posterior distribution, extract the effects of …
j b, bĀiŪz f đbi j bi, bĀiŪ, then we can write out its posterior distribution, extract the effects of …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
…, V Haroutunian, AM Hartmann, FA Henskens… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …
fully understood, despite hundreds of published structural brain imaging studies. This study …
[HTML][HTML] Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …
understood, and reported disease effects on the brain vary widely between studies. In an …
[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
…, V Haroutunian, AM Hartmann, FA Henskens… - The American Journal of …, 2014 - cell.com
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium …
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium …
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
…, V Haroutunian, AM Hartmann, FA Henskens… - Biological …, 2021 - Elsevier
Background Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease,
are calculated as a weighted count of risk alleles identified in genome-wide association …
are calculated as a weighted count of risk alleles identified in genome-wide association …
The australian eeg database
…, DB Williams, F Henskens - Clinical EEG and …, 2005 - journals.sagepub.com
The Australian EEG Database is a web-based de-identified searchable database of 18,500
EEG records recorded at a regional public hospital over an 11-year period. Patients range in …
EEG records recorded at a regional public hospital over an 11-year period. Patients range in …
[PDF][PDF] Estimation of genetic correlation via linkage disequilibrium score regression and genomic restricted maximum likelihood
…, V Haroutunian, AM Hartmann, FA Henskens… - The American Journal of …, 2018 - cell.com
Genetic correlation is a key population parameter that describes the shared genetic architecture
of complex traits and diseases. It can be estimated by current state-of-art methods, ie, …
of complex traits and diseases. It can be estimated by current state-of-art methods, ie, …