User profiles for F. Henskens

Frans Henskens

Conjoint Professor, School of Medicine & Public Health, University of Newcastle
Verified email at newcastle.edu.au
Cited by 29112

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

…, AM Hartmann, C Harvey, C Hayward, FA Henskens… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores

…, V Haroutunian, AM Hartmann, FA Henskens… - The american journal of …, 2015 - cell.com
… If we sample the effect to be non-zero and again make the simplifying assumption that f đbi
j b, bĀiŪz f đbi j bi, bĀiŪ, then we can write out its posterior distribution, extract the effects of …

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

…, V Haroutunian, AM Hartmann, FA Henskens… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …

[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …

…, VL Cropley, JM Fullerton, MJ Green, FA Henskens… - Biological …, 2018 - Elsevier
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

[HTML][HTML] Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

…, R Hashimoto, SN Hatton, FA Henskens… - Molecular …, 2018 - nature.com
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …

[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

…, V Haroutunian, AM Hartmann, FA Henskens… - The American Journal of …, 2014 - cell.com
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA

…, I Nenadić, MJ Cairns, M Seal, U Schall, F Henskens… - Neuroimage, 2020 - Elsevier
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium …

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

…, V Haroutunian, AM Hartmann, FA Henskens… - Biological …, 2021 - Elsevier
Background Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease,
are calculated as a weighted count of risk alleles identified in genome-wide association …

The australian eeg database

…, DB Williams, F Henskens - Clinical EEG and …, 2005 - journals.sagepub.com
The Australian EEG Database is a web-based de-identified searchable database of 18,500
EEG records recorded at a regional public hospital over an 11-year period. Patients range in …

[PDF][PDF] Estimation of genetic correlation via linkage disequilibrium score regression and genomic restricted maximum likelihood

…, V Haroutunian, AM Hartmann, FA Henskens… - The American Journal of …, 2018 - cell.com
Genetic correlation is a key population parameter that describes the shared genetic architecture
of complex traits and diseases. It can be estimated by current state-of-art methods, ie, …