[HTML][HTML] Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

…, C Betts, A Blocker, J Bredno, R Calef, G Cann… - Annals of …, 2020 - Elsevier
Background Early cancer detection could identify tumors at a time when outcomes are
superior and treatment is less morbid. This prospective case-control sub-study (from …

[HTML][HTML] mRNA-Seq of single prostate cancer circulating tumor cells reveals recapitulation of gene expression and pathways found in prostate cancer

GM Cann, ZG Gulzar, S Cooper, R Li, S Luo, M Tat… - PloS one, 2012 - journals.plos.org
Circulating tumor cells (CTC) mediate metastatic spread of many solid tumors and enumeration
of CTCs is currently used as a prognostic indicator of survival in metastatic prostate …

[HTML][HTML] A DNA methylation atlas of normal human cell types

N Loyfer, J Magenheim, A Peretz, G Cann, J Bredno… - Nature, 2023 - nature.com
DNA methylation is a fundamental epigenetic mark that governs gene expression and
chromatin organization, thus providing a window into cellular identity and developmental …

The α4Subunit of Integrin Is Important for Neural Crest Cell Migration

SH Kil, CE Krull, G Cann, D Clegg… - Developmental …, 1998 - Elsevier
We identify the α 4 subunit of integrin as a predominant integrin expressed by neural crest
cells in both avian and murine embryos. Using degenerate primers, we obtained a PCR …

Developmental expression of LC3α and β: absence of fibronectin or autophagy phenotype in LC3β knockout mice

GM Cann, C Guignabert, L Ying… - … dynamics: an official …, 2008 - Wiley Online Library
Murine light chain 3 (LC3) exists as two isoforms, LC3α and β: LC3β is an RNA‐binding protein
that enhances fibronectin (FN) mRNA translation, and is also a marker of autophagy. We …

Remote immune processes revealed by immune-derived circulating cell-free DNA

…, JM Caldwell, M Rochman, A Jamshidi, G Cann… - Elife, 2021 - elifesciences.org
Blood cell counts often fail to report on immune processes occurring in remote tissues. Here,
we use immune cell type-specific methylation patterns in circulating cell-free DNA (cfDNA) …

SF/HGF is a mediator between limb patterning and muscle development

…, A Bonafede, V Dathe, M Sachs, G Cann… - …, 1999 - journals.biologists.com
Scatter factor/hepatocyte growth factor (SF/HGF) is known to be involved in the detachment
of myogenic precursor cells from the lateral dermomyotomes and their subsequent migration …

Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension

…, K Desai, S Hacker, L Wang, GM Cann… - Circulation …, 2005 - Am Heart Assoc
Transgenic mice overexpressing the calcium binding protein, S100A4/Mts1, occasionally
develop severe pulmonary vascular obstructive disease. To understand what underlies this …

[HTML][HTML] Hydrate assemblage stability of calcium sulfoaluminate-belite cements with varying sulfate content

…, S Cockburn, M Hayes, MJ Angus, G Cann… - … and Building Materials, 2023 - Elsevier
… Cement hydration as a function of time was plotted using the 5 parameter logistic (5PL)
function, and was based around 100 g of clinker with the additional calcium sulfate then added […

[HTML][HTML] Megakaryocyte-and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels

…, Y Kalish, A Klochendler, G Cann… - Nature …, 2023 - nature.com
… For preparing PRP, whole blood (anticoagulated with 3.2 g% of sodium citrate, ratio 1:10)
was centrifuged at 110 g for 10 min at room temperature. 0.5 ml aliquot was collected for …