[HTML][HTML] CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
…, DR Bell, FJ Gonzalez, GR Robertson - The Journal of …, 2000 - Am Soc Clin Investig
Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease have similar pathological
features. Because CYP2E1 plays a key role in alcoholic liver disease with its ability to …
features. Because CYP2E1 plays a key role in alcoholic liver disease with its ability to …
[HTML][HTML] A switch from white to brown fat increases energy expenditure in cancer-associated cachexia
Cancer-associated cachexia (CAC) is a wasting syndrome characterized by systemic inflammation,
body weight loss, atrophy of white adipose tissue (WAT) and skeletal muscle. Limited …
body weight loss, atrophy of white adipose tissue (WAT) and skeletal muscle. Limited …
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
…, GC Farrell, R Schriemer, GR Robertson - Journal of hepatology, 2002 - Elsevier
Background/Aims: Obesity is associated with hyperleptinemia and is also a risk factor for
fibrosis and severity of fibrosis in several chronic liver diseases. The correlation between …
fibrosis and severity of fibrosis in several chronic liver diseases. The correlation between …
Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice
E Ip, GC Farrell, G Robertson, P Hall, R Kirsch… - Hepatology, 2003 - Elsevier
We have proposed that steatohepatitis results from reactive oxygen species (ROS) acting
on accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a (Cyp4a…
on accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a (Cyp4a…
II. Cytochrome P-450 enzymes and oxidative stress
G Robertson, I Leclercq… - American Journal of …, 2001 - journals.physiology.org
Oxidative stress is present in the liver of humans with steatosis and nonalcoholic steatohepatitis
(NASH) and is a plausible mediator of cellular injury, inflammatory recruitment, and …
(NASH) and is a plausible mediator of cellular injury, inflammatory recruitment, and …
Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer
…, M Piquette-Miller, KW Renton, GR Robertson… - Drug Metabolism and …, 2008 - ASPET
This article is a report on a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics and held at the Experimental Biology 07 meeting in …
and Experimental Therapeutics and held at the Experimental Biology 07 meeting in …
[PDF][PDF] Administration of the potent PPARα agonist, Wy‐14,643, reverses nutritional fibrosis and steatohepatitis in mice
E Ip, G Farrell, P Hall, G Robertson, I Leclercq - Hepatology, 2004 - Wiley Online Library
Administration of a methionine and choline deficient (MCD) diet to rodents causes progressive
fibrosing steatohepatitis pathologically similar to human metabolic steatohepatitis. We …
fibrosing steatohepatitis pathologically similar to human metabolic steatohepatitis. We …
Transcriptional regulation of the human CYP3A4gene by the constitutive androstane receptor
…, E Hodgson, DJ D'Costa, GR Robertson… - Molecular …, 2002 - ASPET
Cytochrome P450 3A4 (CYP3A4), the predominant P450 expressed in adult human liver, is
both constitutively expressed and transcriptionally activated by a variety of structurally …
both constitutively expressed and transcriptionally activated by a variety of structurally …
[PDF][PDF] Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice
RS McCuskey, Y Ito, GR Robertson… - …, 2004 - Wiley Online Library
In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance
for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear …
for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear …
Cancer cachexia: malignant inflammation, tumorkines, and metabolic mayhem
M Tsoli, G Robertson - Trends in Endocrinology & Metabolism, 2013 - cell.com
Cachexia has a devastating impact on survival and quality of life for many cancer patients. A
better understanding of the underlying mechanisms leading to the complex metabolic …
better understanding of the underlying mechanisms leading to the complex metabolic …