Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease have similar pathological
features. Because CYP2E1 plays a key role in alcoholic liver disease with its ability to …

Cancer-associated cachexia (CAC) is a wasting syndrome characterized by systemic inflammation,
body weight loss, atrophy of white adipose tissue (WAT) and skeletal muscle. Limited …

Background/Aims: Obesity is associated with hyperleptinemia and is also a risk factor for
fibrosis and severity of fibrosis in several chronic liver diseases. The correlation between …

We have proposed that steatohepatitis results from reactive oxygen species (ROS) acting
on accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a (Cyp4a…

Oxidative stress is present in the liver of humans with steatosis and nonalcoholic steatohepatitis
(NASH) and is a plausible mediator of cellular injury, inflammatory recruitment, and …

This article is a report on a symposium sponsored by the American Society for Pharmacology
and Experimental Therapeutics and held at the Experimental Biology 07 meeting in …

Administration of a methionine and choline deficient (MCD) diet to rodents causes progressive
fibrosing steatohepatitis pathologically similar to human metabolic steatohepatitis. We …

Cytochrome P450 3A4 (CYP3A4), the predominant P450 expressed in adult human liver, is
both constitutively expressed and transcriptionally activated by a variety of structurally …

In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance
for hepatocellular function, perisinusoidal fibrosis, and portal hypertension. It is unclear …

Cachexia has a devastating impact on survival and quality of life for many cancer patients. A
better understanding of the underlying mechanisms leading to the complex metabolic …