The present study considers the ways in which redox enzyme modules are coupled in living
cells for linking reductive and oxidative half-reactions, and then reviews examples in which …

Enzymes dependent on nicotinamide cofactors are important components of the expanding
range of asymmetric synthetic techniques. New challenges in asymmetric catalysis are …

We describe a new approach to selective H 2 ‐driven hydrogenation that exploits a sequence
of enzymes immobilised on carbon particles. We used a catalyst system that comprised …

We describe the implementation of a system of immobilised enzymes for H2-driven NADH
recycling coupled to a selective biotransformation to enable H2-driven biocatalysis in flow. …

Pyrolytic graphite particles modified with hydrogenase and an NAD+/NADH cycling enzyme
provide a modular heterogeneous catalyst system for regeneration of oxidised or reduced …

Deuterium-labeled nicotinamide cofactors such as [4- 2 H]-NADH can be used as mechanistic
probes in biological redox processes and offer a route to the synthesis of selectively [ 2 H] …

The high selectivity of biocatalysis offers a valuable method for greener, more efficient
production of enantiopure molecules. Operating immobilised enzymes in flow reactors can …

Heterogeneous biocatalytic hydrogenation is an attractive strategy for clean, enantioselective
CX reduction. This approach relies on enzymes powered by H2-driven NADH recycling. …

Translation of redox biocatalysis into a commercial hydrogenation flow reactor, with in-built
electrolytic H 2 generation, was achieved using immobilized enzyme systems. Carbon-…

We demonstrate a recycling system for synthetic nicotinamide cofactor analogues using a
soluble hydrogenase with turnover number of >1000 for reduction of the cofactor analogues by …