User profiles for H. Geys
 | Helena GeysJanssen Pharma R&D + Hasselt University Verified email at its.jnj.com Cited by 3963 |
The validation of surrogate endpoints in meta-analyses of randomized experiments
… In practice, situations abound with binary and time-to-event endpoints, and more generally
with surrogate and final endpoints of a different type (Molenberghs, Geys and Buyse, …
with surrogate and final endpoints of a different type (Molenberghs, Geys and Buyse, …
Statistical challenges in the evaluation of surrogate endpoints in randomized trials
The validation of surrogate endpoints has been studied by Prentice, who presented a
definition as well as a set of criteria that are equivalent if the surrogate and true endpoints are …
definition as well as a set of criteria that are equivalent if the surrogate and true endpoints are …
Validation of surrogate end points in multiple randomized clinical trials with failure time end points
… and Helena Geys and Didier Renard … Geys and D. Renard … and Geys, H. 2000) The validation
of surrogate endpoints in meta-analysis of randomized experiments. Biostatistics, 1, 49±67. …
of surrogate endpoints in meta-analysis of randomized experiments. Biostatistics, 1, 49±67. …
[BOOK][B] Topics in modelling of clustered data
… Helena Geys is postdoctoral researcher at the Limburgs Universitair Centrum in Belgium.
Her … Geys published methodological work on clustered non-normal data with applications in …
Her … Geys published methodological work on clustered non-normal data with applications in …
Pseudolikelihood modeling of multivariate outcomes in developmental toxicology
The primary goal of this article is to determine benchmark doses based on the ethylene glycol
study, which comprises data from a developmental toxicity study in mice. Because the data …
study, which comprises data from a developmental toxicity study in mice. Because the data …
A pairwise likelihood approach to estimation in multilevel probit models
A pairwise likelihood (PL) estimation procedure is examined in multilevel models with binary
responses and probit link. The PL is obtained as the product of bivariate likelihoods for …
responses and probit link. The PL is obtained as the product of bivariate likelihoods for …
Applying concepts of generalizability theory on clinical trial data to investigate sources of variation and their impact on reliability
… to follow an N(0, τ 2 H i ) law. The serial correlation matrix H i only depends on i through the
… The structure of the matrix H i is determined through the autocorrelation function ρ(t ij −t ik ). …
… The structure of the matrix H i is determined through the autocorrelation function ρ(t ij −t ik ). …
AI/ML models to predict the severity of drug-induced liver injury for small molecules
…, O Irrechukwu, MD Aleo, H Geys… - Chemical Research …, 2023 - ACS Publications
… Aleo data curation, formal analysis; Helena Geys funding acquisition, resources, writing-review
& editing; Kaushik Mitra resources, supervision, validation, writing-review & editing; …
& editing; Kaushik Mitra resources, supervision, validation, writing-review & editing; …
The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative
…, DJ Gallacher, H Geys, P Jarvis, H Ju… - Toxicological …, 2014 - academic.oup.com
It is widely accepted that more needs to be done to bring new, safe, and efficacious drugs to
the market. Cardiovascular toxicity detected both in early drug discovery as well as in the …
the market. Cardiovascular toxicity detected both in early drug discovery as well as in the …
Recommendations on the statistical analysis of the Comet assay
J Bright, M Aylott, S Bate, H Geys, P Jarvis… - Pharmaceutical …, 2011 - Wiley Online Library
In 2010, the Statisticians in the Pharmaceutical Industry (PSI) Toxicology Special Interest
Group met to discuss the design and analysis of the Comet assay. The Comet assay is one …
Group met to discuss the design and analysis of the Comet assay. The Comet assay is one …