User profiles for H. Macdonald

Heather Macdonald

Research Associate, Active Aging Research Team, UBC
Verified email at ubc.ca
Cited by 6568

NKT cells: what's in a name?

DI Godfrey, HR MacDonald, M Kronenberg… - Nature Reviews …, 2004 - nature.com
Recent years have seen so-called natural killer T (NKT) cells emerge as important regulators
of the immune response. The existence of NKT-cell subsets, and other types of T cell that …

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

HR MacDonald, R Schneider, RK Lees, RC Howe… - Nature, 1988 - nature.com
T lymphocytes reactive with the product of the Mls a -allele of the minor lymphocyte stimulating
(Mls) locus use a predominant T-cell receptor β-chain variable gene segment (V β6 ). …

Notch regulation of lymphocyte development and function

F Radtke, A Wilson, SJC Mancini, HR MacDonald - Nature immunology, 2004 - nature.com
Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes
during fetal and postnatal development. Mammals have four Notch receptors that bind five …

Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide

…, D Moher, DG Altman, V Barbour, H Macdonald… - Bmj, 2014 - bmj.com
… in medical statistics4, David Moher senior scientist5, Douglas G Altman professor of
statistics in medicine6, Virginia Barbour medicine editorial director, PLOS7, Helen Macdonald

[HTML][HTML] Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

…, L Eshkind, E Bockamp, P Lio, HR MacDonald… - Cell, 2008 - cell.com
Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of
all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns …

Common genetic determinants of vitamin D insufficiency: a genome-wide association study

…, WD Fraser, AL Hartikainen, G Zhai, HM Macdonald… - The Lancet, 2010 - thelancet.com
Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …

[PDF][PDF] Deficient T cell fate specification in mice with an induced inactivation of Notch1

…, G Stark, M Bauer, J van Meerwijk, HR MacDonald… - Immunity, 1999 - cell.com
Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was flanked …

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily

…, CJ March, D Cosman, MB Widmer, HR MacDonald… - Science, 1988 - science.org
Interleukin-1 alpha and -1 beta (IL-1α and IL-1β) are cytokines that participate in the regulation
of immune responses, inflammatory reactions, and hematopoiesis. A direct expression …

A case‐control family history study of autism

P Bolton, H Macdonald, A Pickles… - Journal of child …, 1994 - Wiley Online Library
Family history data on 99 autistic and 36 Down's syndrome probands are reported. They
confirmed a raised familial loading for both autism and more broadly defined pervasive …

A living WHO guideline on drugs for covid-19

…, T Agoritsas, L Askie, L Lytvyn, YS Leo, H Macdonald… - 2022 - scholar.sun.ac.za
This living guideline by Arnav Agarwal and colleagues (BMJ 2020; 370: m3379, doi: 10.1136/bmj.
m3379) was last updated on 22 April 2022, but the infographic contained two dosing …