Background: Familial hypercholesterolaemia (FH) affects approximately 1 in 500 people (10
million world-wide) and the elevated serum cholesterol concentrations lead to a more than …

Objectives: To estimate the efficacy of dietary advice to lower blood total cholesterol
concentration in free-living subjects and to investigate the efficacy of different dietary …

Background Type 2 diabetes is associated with a substantially increased risk of cardiovascular
disease, but the role of lipid-lowering therapy with statins for the primary prevention of …

To evaluate whether screening for familial hypercholesterolaemia (FH) is appropriate; to
determine which system of screening is most acceptable and cost-effective; to assess the …

Background During the United Kingdom Prospective Diabetes Study (UKPDS), patients with
type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of …

Objective: To determine the relation between exposure to glycaemia over time and the risk
of macrovascular or microvascular complications in patients with type 2 diabetes. Design: …

Objective: To evaluate baseline risk factors for coronary artery disease in patients with type
2 diabetes mellitus. Design: A stepwise selection procedure, adjusting for age and sex, was …

Objective: To determine the relation between systolic blood pressure over time and the risk
of macrovascular or microvascular complications in patients with type 2 diabetes. Design: …

Background Post-trial monitoring of patients in the United Kingdom Prospective Diabetes
Study (UKPDS) examined whether risk reductions for microvascular and macrovascular …

… HAW Neil, LS Roe, and S Ziebland conceived the study. The final protocol was designed
in … JH John and HAW Neil wrote the paper and all authors were involved in interpreting the …