The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the …

…, K Birnie, J Busby, B Delaney, H Downing… - Health technology …, 2016 - orca.cardiff.ac.uk
Background It is not clear which young children presenting acutely unwell to primary care
should be investigated for urinary tract infection (UTI) and whether or not dipstick testing …

Improving the diagnosis and treatment of urinary tract infection in young children in primary care: results from the DUTY prospective diagnostic cohort study

…, J Dudley, J Van Der Voort, H Downing… - The Annals of Family …, 2016 - Annals Family Med
PURPOSE Up to 50% of urinary tract infections (UTIs) in young children are missed in primary
care. Urine culture is essential for diagnosis, but urine collection is often difficult. Our aim …

Effect of oral prednisolone on symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection: a randomized clinical trial

…, M May, S Hollinghurst, FE Carroll, H Downing… - Jama, 2017 - jamanetwork.com
Importance Acute lower respiratory tract infection is common and often treated inappropriately
in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient …

[HTML][HTML] The diagnosis of urinary tract infections in young children (DUTY): protocol for a diagnostic and prospective observational study to derive and validate a …

H Downing, E Thomas-Jones, M Gal, CA Waldron… - BMC infectious …, 2012 - Springer
Background Urinary tract infection (UTI) is common in children, and may cause serious
illness and recurrent symptoms. However, obtaining a urine sample from young children in …

Childhood urinary tract infection in primary care: a prospective observational study of prevalence, diagnosis, treatment, and recovery

…, J Dudley, K Rumsby, H Downing… - British Journal of …, 2015 - bjgp.org
Background The prevalence of targeted and serendipitous treatment for, and associated
recovery from, urinary tract infection (UTI) in pre-school children is unknown. Aim To determine …

[HTML][HTML] Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue In Teenagers on the interNET in the NHS) compared to Activity Management to …

…, K Garfield, C Metcalfe, R Parslow, H Downing… - Trials, 2018 - Springer
Background Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is
a relatively common and disabling condition. The National Institute for Health and Clinical …

[HTML][HTML] Developmental trends in the facilitation of multisensory objects with distractors

HC Downing, A Barutchu, SG Crewther - Frontiers in psychology, 2015 - frontiersin.org
Sensory integration and the ability to discriminate target objects from distractors are critical
to survival, yet the developmental trajectories of these abilities are unknown. This study …

[HTML][HTML] Evaluation and deployment of isotype-specific salivary antibody assays for detecting previous SARS-CoV-2 infection in children and adults

…, N Grace, GG Livera, L Bishop, H Downing… - Communications …, 2023 - nature.com
Background Saliva is easily obtainable non-invasively and potentially suitable for detecting
both current and previous SARS-CoV-2 infection, but there is limited evidence on the utility of …

[HTML][HTML] Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT.

AD Hay, H Downing, NA Francis… - Health Technology …, 2019 - ncbi.nlm.nih.gov
BACKGROUND Acute otitis media (AOM) is a common reason for primary care consultations
and antibiotic prescribing in children. Options for improved pain control may influence …

Empiric antibiotic treatment for urinary tract infection in preschool children: susceptibilities of urine sample isolates

…, K Rumsby, P Little, H Downing… - Family …, 2016 - academic.oup.com
Background. Antibiotic treatment recommendations based on susceptibility data from
routinely submitted urine samples may be biased because of variation in sampling, laboratory …