Background Reasons for intentional non-adherence to guidelines are largely unknown. The
objective of this systematic review was to gain insight into and categorize reasons for …

In acute infectious conjunctivitis the general practitioner has to distinguish a bacterial cause
from a viral one to select the patients who are most likely to benefit from antibiotic treatment. …

Objective To validate all diagnostic prediction models for ruling out pulmonary embolism that
are easily applicable in primary care. Design Systematic review followed by independent …

Controversy remains about the value of combined treatment with levothyroxine (LT 4 ) and
liothyronine (LT 3 ), compared with LT 4 alone in primary hypothyroidism. We compared …

Objective To validate the use of the Wells clinical decision rule combined with a point of care
D-dimer test to safely exclude pulmonary embolism in primary care. Design Prospective …

Objective To find an efficient set of diagnostic indicators that are optimally informative in the
diagnosis of a bacterial origin of acute infectious conjunctivitis. Design Cohort study …

Background: Up to 90% of patients referred for ultrasonography with suspected deep venous
thrombosis (DVT) of the leg do not have the disease. Objective: To evaluate the safety and …

Background: Screening for major depression with the Patient Health Questionnaire-9 (PHQ-9)
can be done using a cutoff or the PHQ-9 diagnostic algorithm. Many primary studies …

PURPOSE Follow-up after colorectal cancer treatment with curative intent aims to detect
recurrences and metachronous tumors in a timely manner. The objective of this study is to …

Background In Western countries, better knowledge about patient-related determinants of
treatment adherence (medication and lifestyle) is needed to improve treatment adherence and …