This statement examines the cardiovascular complications of diabetes mellitus and considers
opportunities for their prevention. These complications include coronary heart disease (…

Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Individuals with type 2 diabetes mellitus have increased cardiovascular disease risk compared
with those without diabetes. Treatment of the residual risk, other than blood pressure and …

The potassium channel from Streptomyces lividans is an integral membrane protein with
sequence similarity to all known K + channels, particularly in the pore region. X-ray analysis …

A fraction of a genetically homogeneous microbial population may survive exposure to stress
such as antibiotic treatment. Unlike resistant mutants, cells regrown from such persistent …

The gene product of the ob locus is important in the regulation of body weight. The ob product
was shown to be present as a 16-kilodalton protein in mouse and human plasma but was …

Background Both lipid-modifying therapy and antioxidant vitamins are thought to have
benefit in patients with coronary disease. We studied simvastatin–niacin and antioxidant-vitamin …

Analytical chemists and biochemists have long sought accurate, sensitive methods for
determining the molecu-lar masses of biopolymers such as proteins and carbohydrates. Tradi-…

Voltage-dependent K + channels are members of the family of voltage-dependent cation (K
+ , Na + and Ca 2+ ) channels that open and allow ion conduction in response to changes in …

The ClC chloride channels catalyse the selective flow of Cl - ions across cell membranes,
thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across …