[HTML][HTML] Role of the IL-33/ST2 axis in cardiovascular disease: A systematic review and meta-analysis
Y Sun, H Pavey, I Wilkinson, M Fisk - PLoS One, 2021 - journals.plos.org
… In this meta-analysis, several IL-33 studies were not included due to levels of IL-33 being
below the detection limit of the assay [24, 29, 30]. A further point of consideration is that IL-33 …
below the detection limit of the assay [24, 29, 30]. A further point of consideration is that IL-33 …
Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1β on tuberculosis
RJ Wilkinson, P Patel, M Llewelyn, CS Hirsch… - The Journal of …, 1999 - rupress.org
… β, IL-10, and, specifically in the case of IL-1β, the IL-1 receptor antagonist (IL-1Ra), a pure
antagonist of the IL-1 type 1 receptor (IL-… The genes coding for both IL-1β and the IL-1Ra gene …
antagonist of the IL-1 type 1 receptor (IL-… The genes coding for both IL-1β and the IL-1Ra gene …
Distinct, specific IL-17-and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response
We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by
human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ T …
human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ T …
[PDF][PDF] Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation
SM Hurst, TS Wilkinson, RM McLoughlin, S Jones… - Immunity, 2001 - cell.com
… /IL-6 complex in peritoof IL-6 or sIL-6R alone had no affect on HPMC ELR CXC neal inflammation,
IL-6-deficient (IL… with SES and IL-6 signaling reconstituted through with the sIL-6R/IL-6 …
IL-6-deficient (IL… with SES and IL-6 signaling reconstituted through with the sIL-6R/IL-6 …
[HTML][HTML] Structural characterisation reveals mechanism of IL-13-neutralising monoclonal antibody tralokinumab as inhibition of binding to IL-13Rα1 and IL-13Rα2
…, R Minter, F Uddin, G Colice, T Wilkinson… - Journal of molecular …, 2017 - Elsevier
… of residues in helices D and A of IL-13. It is mostly light … IL-13 pharmacodynamic effect by
binding to IL-13 helices A and D, thus preventing IL-13 from interacting with IL-13Rα1 and IL…
binding to IL-13 helices A and D, thus preventing IL-13 from interacting with IL-13Rα1 and IL…
[PDF][PDF] … 1 Diabetic Children and siblings share a decrease in dendritic cell and monocyte numbers but are differentiated by expansion of CD4+ T cells expressing IL-17
A Wilkinson, L Bian, D Khalil, K Gibbons… - J Clin Cell Immunol …, 2011 - academia.edu
… evidence from a human study supports a role for IL-2 in the development of IL-17 cells from
TReg cells [39]. nevertheless, our data suggest that in diabetic children, combined IL-2 and IL…
TReg cells [39]. nevertheless, our data suggest that in diabetic children, combined IL-2 and IL…
[PDF][PDF] Monoclonal antibody-mediated targeting of CD123, IL-3 receptor α chain, eliminates human acute myeloid leukemic stem cells
…, HS Ramshaw, SJ Busfield, AG Peoppl, L Wilkinson… - Cell stem cell, 2009 - cell.com
… in inhibiting IL-3-mediated growth advantages on AML-LSCs, we demonstrate that both the
unsorted and the CD34+CD38À subpopulations of AML cells proliferate and survive via IL-3-…
unsorted and the CD34+CD38À subpopulations of AML cells proliferate and survive via IL-3-…
[HTML][HTML] Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation
…, J Witowski, RL Robson, TS Wilkinson… - The Journal of …, 2003 - Am Soc Clin Investig
… derived from Staphylococcus epidermidis or IL-1β as a … important roles for both IL-6,
through its soluble IL-6 receptor (… by affecting the local activities of IL-1β and IL-6. In this way, …
through its soluble IL-6 receptor (… by affecting the local activities of IL-1β and IL-6. In this way, …
[HTML][HTML] … , ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in …
P Woo, N Wilkinson, AM Prieur, T Southwood… - Arthritis research & …, 2005 - Springer
… regions of a mouse anti-human IL-6 receptor monoclonal antibody onto human … IL-6 receptor,
thus inhibiting the binding of IL-6 to its receptor and its pro-inflammatory activity [20]. As IL-…
thus inhibiting the binding of IL-6 to its receptor and its pro-inflammatory activity [20]. As IL-…
Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms
…, S Horiuchi, LW Morgan, TS Wilkinson… - The Journal of …, 2004 - journals.aai.org
… with IL-6, both isoforms specifically inhibited the IL-1β-… which induction of peritoneal
inflammation in IL-6-deficient (IL-6−/−… Reconstitution of IL-6 signaling in IL-6−/− mice with IL-6 and …
inflammation in IL-6-deficient (IL-6−/−… Reconstitution of IL-6 signaling in IL-6−/− mice with IL-6 and …