This article aims to offer an updated review of the effects of smoking on inflammatory bowel
disease, and provide a review of the methods of achieving smoking cessation. A systematic …

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …

Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs …

… condition is likely mediated by binding of the antibodies to integrin dimers that are not
specific to the gut, leading to impaired leukocyte migration to the central nervous system and JC …

Elastin is a major component of tissues such as lung and blood vessels, and endows them
with the long-range elasticity necessary for their physiological functions. Recent research has …

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously
unknown susceptibility locus at ECM1. We also show that several risk loci are common to …

Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …

Background Etrolizumab is a humanised monoclonal antibody that selectively binds the β7
subunit of the heterodimeric integrins α4β7 and αEβ7. We aimed to assess etrolizumab in …

Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …