Dynamin-related proteins (DRPs) are large self-assembling GTPases whose common
function is to regulate membrane dynamics in a variety of cellular processes. Dnm1, which is a …

Previous studies of the Hpa I cleavage site-sickle cell hemoglobin gene linkage in various
African populations suggested that the sickle gene arose independently more than once. In …

Mitochondria are dynamic organelles that undergo cycles of fission and fusion. The yeast
dynamin-related protein Dnm1 has been localized to sites of mitochondrial division. Using cryo-…

The transfer of intact mitochondria between heterogeneous cell types has been confirmed
in various settings, including cancer. However, the functional implications of mitochondria …

Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles
associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep …

The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of
clathrin-coated pits, but the specific structural interactions and conformational changes that …

Dynamin 1‐like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and
dysfunction of DNM1L has been implicated in several neurological disorders. To study the …

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Sterols are transferred between cellular membranes by vesicular and poorly understood
nonvesicular pathways. Oxysterol-binding protein–related proteins (ORPs) have been …

Background Immunosuppressive and anti-cytokine treatment may have a protective effect
for patients with COVID-19. Understanding the immune cell states shared between COVID-19 …