BACKGROUND The evidence base which supported the National Institute for Health and
Clinical Excellence (NICE) published Clinical Guideline 3 was limited and 50% was graded as …

Objectives: Many claims are made that complementary medicine use is a substantial and
growing part of health-care behaviour. Estimates of practitioner visits in the USA and Australia …

Background We report a prospective randomised comparison between laparoscopic and
small-incision cholecystectomy in 200 patients which was designed to eliminate bias for or …

An important methodological issue in measuring health-related quality of life is whether
instruments such as SF-36 and EQ can be used on an elderly population. This paper aims to test …

To assess the value of promoting health through exercise, we review what is known about
the medical and medical care resource costs and benefits of exercise. Literatu re searches …

A national study of exercise related morbidity (ERM) in England and Wales was carried out
using a postal questionnaire sent to 28,857 adults aged 16-45 years. The questionnaire …

Objective: To assess the effect of the London helicopter emergency medical service on survival
after trauma. Design: Prospective comparison of outcomes in cohorts of seriously injured …

Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising
the validity of conclusions and it is essential to distinguish pre-planned from unplanned …

Objective: To assess the effect of leaflets on promoting informed choice in women using
maternity services. Design: Cluster trial, with maternity units randomised to use leaflets (…

Objective: To assess the cost effectiveness of a community based exercise programme as a
population wide public health intervention for older adults. Design: Pragmatic, cluster …