[HTML][HTML] Insulin action, type 2 diabetes, and branched-chain amino acids: a two-way street
Background A strong association of obesity and insulin resistance with increased circulating
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …
A systematic review on the use of fibrin glue for peripheral nerve repair
Background: Although Tisseel (Baxter, Deerfield, Ill.) was introduced over 30 years ago, the
literature remains scant regarding its use and efficacy in peripheral nerve repairs. The goal …
literature remains scant regarding its use and efficacy in peripheral nerve repairs. The goal …
Gut microbiota from twins discordant for obesity modulate metabolism in mice
… cohousing group, j, as follows: I n v a s i o n S c o r e i j = l o g 2 ( A i j B i j ) where A i j is the
… all fecal samples collected from group j after cohousing, and B i j is its relative abundance in …
… all fecal samples collected from group j after cohousing, and B i j is its relative abundance in …
[HTML][HTML] A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
CB Newgard, J An, JR Bain, MJ Muehlbauer… - Cell metabolism, 2009 - cell.com
Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related
metabolite signature that is suggestive of increased catabolism of BCAA and …
metabolite signature that is suggestive of increased catabolism of BCAA and …
[HTML][HTML] Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
…, RC Noland, D Slentz, M Mosedale, O Ilkayeva, J Bain… - Cell metabolism, 2008 - cell.com
Previous studies have suggested that insulin resistance develops secondary to diminished
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
…, RD Stevens, Y Li, AK Saha, NB Ruderman, JR Bain… - Nature, 2010 - nature.com
Sirtuins are NAD + -dependent protein deacetylases. They mediate adaptive responses to a
variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is …
variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is …
Geochemical and mineralogical aspects of sulfide mine tailings
MBJ Lindsay, MC Moncur, JG Bain, JL Jambor… - Applied …, 2015 - Elsevier
Tailings generated during processing of sulfide ores represent a substantial risk to water
resources. The oxidation of sulfide minerals within tailings deposits can generate low-quality …
resources. The oxidation of sulfide minerals within tailings deposits can generate low-quality …
The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins
Understanding how the human gut microbiota and host are affected by probiotic bacterial
strains requires carefully controlled studies in humans and in mouse models of the gut …
strains requires carefully controlled studies in humans and in mouse models of the gut …
[HTML][HTML] Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition
…, MJ Barratt, J Cheng, J Guruge, M Talcott, JR Bain… - Cell, 2016 - cell.com
Identifying interventions that more effectively promote healthy growth of children with
undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) …
undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) …
[PDF][PDF] Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
…, S Marmor, BK Hubbard, RD Stevens, JR Bain… - Cell metabolism, 2007 - cell.com
Hepatic steatosis, the accumulation of lipids in the liver, is widely believed to result in insulin
resistance. To test the causal relationship between hepatic steatosis and insulin resistance, …
resistance. To test the causal relationship between hepatic steatosis and insulin resistance, …