User profiles for J. Bain

JR Bain

- Verified email at duke.edu - Cited by 23354

james r bain

- Verified email at hhsc.ca - Cited by 5901

[HTML][HTML] Insulin action, type 2 diabetes, and branched-chain amino acids: a two-way street

PJ White, RW McGarrah, MA Herman, JR Bain… - Molecular …, 2021 - Elsevier
Background A strong association of obesity and insulin resistance with increased circulating
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …

A systematic review on the use of fibrin glue for peripheral nerve repair

M Sameem, TJ Wood, JR Bain - Plastic and Reconstructive …, 2011 - journals.lww.com
Background: Although Tisseel (Baxter, Deerfield, Ill.) was introduced over 30 years ago, the
literature remains scant regarding its use and efficacy in peripheral nerve repairs. The goal …

Gut microbiota from twins discordant for obesity modulate metabolism in mice

…, AL Kau, NW Griffin, V Lombard, B Henrissat, JR Bain… - Science, 2013 - science.org
… cohousing group, j, as follows: I n v a s i o n S c o r e i j = l o g 2 ( A i j B i j ) where A i j is the
… all fecal samples collected from group j after cohousing, and B i j is its relative abundance in …

[HTML][HTML] A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

CB Newgard, J An, JR Bain, MJ Muehlbauer… - Cell metabolism, 2009 - cell.com
Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related
metabolite signature that is suggestive of increased catabolism of BCAA and …

[HTML][HTML] Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

…, RC Noland, D Slentz, M Mosedale, O Ilkayeva, J Bain… - Cell metabolism, 2008 - cell.com
Previous studies have suggested that insulin resistance develops secondary to diminished
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

…, RD Stevens, Y Li, AK Saha, NB Ruderman, JR Bain… - Nature, 2010 - nature.com
Sirtuins are NAD + -dependent protein deacetylases. They mediate adaptive responses to a
variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is …

Geochemical and mineralogical aspects of sulfide mine tailings

MBJ Lindsay, MC Moncur, JG Bain, JL Jambor… - Applied …, 2015 - Elsevier
Tailings generated during processing of sulfide ores represent a substantial risk to water
resources. The oxidation of sulfide minerals within tailings deposits can generate low-quality …

The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins

…, CA Lozupone, R Knight, AE Duncan, JR Bain… - Science translational …, 2011 - science.org
Understanding how the human gut microbiota and host are affected by probiotic bacterial
strains requires carefully controlled studies in humans and in mouse models of the gut …

[HTML][HTML] Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition

…, MJ Barratt, J Cheng, J Guruge, M Talcott, JR Bain… - Cell, 2016 - cell.com
Identifying interventions that more effectively promote healthy growth of children with
undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) …

[PDF][PDF] Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver

…, S Marmor, BK Hubbard, RD Stevens, JR Bain… - Cell metabolism, 2007 - cell.com
Hepatic steatosis, the accumulation of lipids in the liver, is widely believed to result in insulin
resistance. To test the causal relationship between hepatic steatosis and insulin resistance, …