… This change also affects the virulence of these bacteria in mice (10), which is due largely
to differences in phagocytosis and killing by polymorphonuclear leukocytes (J. Fierer, …

… Fierer is professor of medicine and pathology and head of the Division of Infectious Diseases,
University of California, San Diego School of Medicine. Drs. Kirkland and Fierer … , Fierer J. …

… Cloned spvB can complement a non-polar spvB mutant, but spvB without spvC does not
have a detectable virulence phenotype (Guiney and Fierer, unpublished). These results strongly …

Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory
response in the adjacent intestinal mucosa. The present studies asked whether colon …

In an effort to decrease deaths from gram-negative bacteremia and endotoxin shock, we
treated bacteremic patients with human antiserum to endotoxin (lipopolysaccharide) core. …

Golden color imparted by carotenoid pigments is the eponymous feature of the human
pathogen Staphylococcus aureus. Here we demonstrate a role of this hallmark phenotype in …

Protein interactions with peptides generally have low thermodynamic and mechanical
stability. Streptococcus pyogenes fibronectin-binding protein FbaB contains a domain with a …

IKKβ-dependent NF-κB activation plays a key role in innate immunity and inflammation, and
inhibition of IKKβ has been considered as a likely anti-inflammatory therapy. Surprisingly, …

… Eckmann, L., MF Kagnoff, and J. Fierer. 1995. Intestinal epithelial cells as watchdogs for the
… Fierer. 1993. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial …

Bacterial invasion of mucosal surfaces results in a rapid influx of polymorphonuclear leukocytes.
The chemotactic stimulus responsible for this response is not known. Since epithelial …