Influenza A pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiology

JS Oxford - Reviews in medical virology, 2000 - Wiley Online Library
Influenza A virus initiated worldwide epidemics (pandemics) in 1918, 1957, 1968 and 1977.
A revised calculation of the 1918–1919 pandemic estimates that 40 million persons died …

The so-called Great Spanish Influenza Pandemic of 1918 may have originated in France in 1916.

JS Oxford - Philosophical Transactions of the Royal Society of …, 2001 - ncbi.nlm.nih.gov
… , in the absence of air travel at that time, suggested to us (JS Oxford, W. Innes, R. Daniels,
R. … Oxford, unpublished data). We cannot exclude the possibility of a Chinese origin of the …

Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trial

…, J Hedrick, HC Jackson, L Huson, P Ward, JS Oxford… - Jama, 2001 - jamanetwork.com
ContextInfluenza virus is easily spread among the household contacts of an infected person,
and prevention of influenza in household contacts can control spread of influenza in the …

The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and …

…, DB Mendel, CY Tai, R Lambkin, L Kelly, JS Oxford… - Antiviral research, 2002 - Elsevier
Oseltamivir carboxylate is a potent and specific inhibitor of influenza A and B neuraminidase
(NA). Oseltamivir phosphate, the ethyl ester prodrug of oseltamivir carboxylate, is the first …

Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study

…, P Laing, C Jameson, JS Oxford… - … Journal of Obstetrics …, 2000 - Wiley Online Library
Objective To determine whether maternal influenza virus infection in the second and third
trimesters of pregnancy results in transplacental transmission of infection, maternal auto‐…

Structural changes in the haemagglutinin which accompany egg adaptation of an influenza A (H1N1) virus

JS Robertson, JS Bootman, R Newman, JS Oxford… - Virology, 1987 - Elsevier
Antigenic changes are often induced in the haemagglutinin (HA) of human isolates of influenza
A(H1N1) and B viruses during their isolation and propagation in embryonated hens' eggs…

Evidence for host-cell selection of influenza virus antigenic variants

GC Schild, JS Oxford, JC De Jong, RG Webster - Nature, 1983 - nature.com
Extensive antigenic variability and a capricious epidemiology are characteristics of influenza
A and B viruses of man. The haemagglutinin (HA) undergoes frequent and progressive …

Antiviral activity of amantadine: a review of laboratory and clinical data

JS Oxford, A Galbraith - Pharmacology & Therapeutics, 1980 - Elsevier
Influenza A virus has been recognized as a disease entity for several hundred years and
world-wide outbreaks or pandemics have been recorded in England since the seventeenth …

World War I may have allowed the emergence of “Spanish” influenza

JS Oxford, A Sefton, R Jackson, W Innes… - The Lancet infectious …, 2002 - thelancet.com
The 1918 influenza pandemic caused 40 million deaths, and so dwarfed in mortality and
morbidity the preceding pandemic of 1889 and the 1957 and 1968 pandemics. In retrospect, …

A hypothesis: the conjunction of soldiers, gas, pigs, ducks, geese and horses in Northern France during the Great War provided the conditions for the emergence of …

JS Oxford, R Lambkin, A Sefton, R Daniels, A Elliot… - Vaccine, 2005 - Elsevier
The Great Influenza Pandemic of 1918–1919 was a cataclysmic outbreak of infection wherein
over 50 million people died worldwide within 18 months. The question of the origin is …