Since the introduction of new regulations that limit the availability of paracetamol in the UK,
there has been a substantial decrease in the occurrence and severity of cases of …

Since Palmer et al and Ignarro et al showed that vascular endothelial cells could synthesise
nitric oxide (NO), this soluble gas has emerged as an important mediator, messenger and …

Background NICE guidance exists for the use of faecal calprotectin (FC) when irritable bowel
syndrome or inflammatory bowel disease are suspected. Often, however, colorectal cancer …

Background: The role of faecal biomarkers in patients at ‘high risk’ of colorectal cancer (CRC)
is not yet defined. Pre-analytical factors, such as heterogeneity of biomarker distribution …

: Opioids have long been known to inhibit intestinal fluid and electrolyte secretion. They act
locally on central and peripheral opiate receptors where they are rapidly degraded by …

BackgroundNational Institute for Health and Care Excellence have recommended faecal
calprotectin (FC) testing as an option in adults with lower gastrointestinal symptoms for whom …

Background The faecal immunochemical test (FIT) is now available to support clinicians in
the assessment of patients at low risk of colorectal cancer (CRC) and within the bowel cancer …

Objective To evaluate the sensitivity and specificity of the York Faecal Calprotectin Care
Pathway (YFCCP) and undertake a health economics analysis. The YFCCP has been …

The secretagogue 5‐hydroxytryptamine (5‐HT) is implicated in the pathophysiology of
cholera. 5‐HT released from enterochromaffin cells after cholera toxin exposure is thought to …

Cholera toxin and Escherichia coli heat labile toxin (LT) induced intestinal secretion has in
the past been attributed exclusively to an increase in intracellular cAMP whereas E coli heat …