Background NICE guidance exists for the use of faecal calprotectin (FC) when irritable bowel
syndrome or inflammatory bowel disease are suspected. Often, however, colorectal cancer …

Background: The role of faecal biomarkers in patients at ‘high risk’ of colorectal cancer (CRC)
is not yet defined. Pre-analytical factors, such as heterogeneity of biomarker distribution …

BackgroundNational Institute for Health and Care Excellence have recommended faecal
calprotectin (FC) testing as an option in adults with lower gastrointestinal symptoms for whom …

Background The faecal immunochemical test (FIT) is now available to support clinicians in
the assessment of patients at low risk of colorectal cancer (CRC) and within the bowel cancer …

Objective To evaluate the sensitivity and specificity of the York Faecal Calprotectin Care
Pathway (YFCCP) and undertake a health economics analysis. The YFCCP has been …

Background & Aims: Experimental colitis is associated with anorexia that is attenuated by
treatment with an interleukin (IL)-1 receptor antagonist. Serotonin (5-hydroxytryptamine [5-HT]) …

: Opioids have long been known to inhibit intestinal fluid and electrolyte secretion. They act
locally on central and peripheral opiate receptors where they are rapidly degraded by …

Background & Aims: Substance P, a member of the tachykinin family, is a prosecretory
neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory …

Background & Aims: Many consider cholera toxin (CT) and Escherichia coli heat-labile
enterotoxin (LT) to be functionally identical. Both increase intracellular adenosine 3',5'-cyclic …

Background Calprotectin is a heat stable intracellular protein shed by neutrophils into the
intestinal lumen in response to inflammation. Lack of specificity makes its role in the …