Whereas the PROTAC approach to target protein degradation greatly benefits from rational
design, the discovery of small-molecule degraders relies mostly on phenotypic screening …

This study presents bromodomain-selective BET inhibitors that act as antitumor agents and
demonstrates that these molecules have in vivo activity towards neuroblastoma, with …

A library of diarylurea insulin-like growth factor 1 receptor inhibitors was screened for activity
against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium …

Inhibition of intestinal carboxylesterases may allow modification of the pharmacokinetics/pharmacodynamic
profile of existing drugs by altering half-life or toxicity. Since previously …

Influenza is one of the leading causes of disease-related mortalities worldwide. Several
strategies have been implemented during the past decades to hinder the replication cycle of …

Recent changes in water management in Australia have seen a massive increase in
construction of small dams for stock, irrigation and domestic purposes. These are now Australia's …

The purpose of this thesis is to explore lesbian television narratives that shape popular
discourse. My goal is to find and expose the implications of monolithic expressions of queerness …

Augmented Reality (AR) is fast-growing technology that has proved itself in many applications,
including manufacturing environments. Manufacturing engineers benefit in an industrial …

Efficient synthesis of pyrazolopyrimidine libraries. - Abstract - Europe PMC Sign in | Create an
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I am a strong supporter also of many of the Court recommendations, and feel that pre-school
development screening should be in the hands of general practitioners, and that the child …