User profiles for Jeremy P Brown

Jeremy Brown

Harvard TH Chan School of Public Health
Verified email at hsph.harvard.edu
Cited by 1046

Bypass of Senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

JP Brown, W Wei, JM Sedivy - Science, 1997 - science.org
Most somatic cells die after a finite number of cell divisions, a phenomenon described as
senescence. The p21 CIP1/WAF1 gene encodes an inhibitor of cyclin-dependent kinases. …

[HTML][HTML] Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational …

…, CE Morton, K Bhaskaran, JP Brown… - The Lancet …, 2020 - thelancet.com
Background Early descriptions of patients admitted to hospital during the COVID-19 pandemic
showed a lower prevalence of asthma and chronic obstructive pulmonary disease (COPD…

[HTML][HTML] Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study

…, F Lucas, JP Brown, I Kralj-Hans, P Greliak… - The Lancet …, 2017 - thelancet.com
Background Removal of adenomas reduces colorectal cancer incidence and mortality;
however, the benefit of surveillance colonoscopy on colorectal cancer risk remains unclear. We …

Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts

…, AJ Walker, K Bhaskaran, JP Brown… - Annals of the …, 2021 - ard.bmj.com
Objectives To assess the association between routinely prescribed non-steroidal anti-inflammatory
drugs (NSAIDs) and deaths from COVID-19 using OpenSAFELY, a secure analytical …

Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

…, S Bacon, HI McDonald, C Minassian, JP Brown… - bmj, 2021 - bmj.com
Objective To investigate whether risk of infection with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and outcomes of coronavirus disease 2019 (covid-19) differed …

HP1-β is required for development of the cerebral neocortex and neuromuscular junctions

…, J Bullwinkel, Y Yu, W Shi, M Billur, JP Brown… - The Journal of cell …, 2008 - rupress.org
HP1 proteins are thought to be modulators of chromatin organization in all mammals, yet their
exact physiological function remains unknown. In a first attempt to elucidate the function of …

[HTML][HTML] Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic …

…, CE Morton, K Bhaskaran, JP Brown… - The Lancet …, 2021 - thelancet.com
Background Hydroxychloroquine has been shown to inhibit entry of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) into epithelial cells in vitro, but clinical studies …

Plasticity of HP1 proteins in mammalian cells

GK Dialynas, S Terjung, JP Brown… - Journal of cell …, 2007 - journals.biologists.com
We have compared the distribution of endogenous heterochromatin protein 1 (HP1) proteins
(α, β and γ) in different epithelial lines, pluripotent stem cells and embryonic fibroblasts. In …

[PDF][PDF] Mammalian HP1 isoforms have specific roles in heterochromatin structure and organization

…, C Casal, N Kane-Goldsmith, M Vizoso, JP Brown… - Cell reports, 2017 - cell.com
HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β,
and HP1γ play different roles in genome stability, but their precise role in heterochromatin …

Association of relative age in the school year with diagnosis of intellectual disability, attention-deficit/hyperactivity disorder, and depression

A Root, JP Brown, HJ Forbes, K Bhaskaran… - JAMA …, 2019 - jamanetwork.com
Importance Young relative age within the school year has previously been associated with
attention-deficit/hyperactivity disorder (ADHD) diagnosis and, based on limited evidence, …