Frailty is the most problematic expression of population ageing. It is a state of vulnerability to
poor resolution of homoeostasis after a stressor event and is a consequence of cumulative …

Background Cancer survival varies widely between countries. The CONCORD study provides
survival estimates for 1·9 million adults (aged 15–99 years) diagnosed with a first, primary, …

The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the
bacterium evade the immune system and can kill the host during a systemic infection. Two …

Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on
the host cellular machinery to replicate. Identifying which host proteins and complexes come …

Knowledge of the weight, volume, and center of mass of segments of the human body is of
significance to research in such diverse fields as physical educa-tion, prosthetics, and space …

The availability of accurately aligned, whole-body anatomical (CT) and functional (PET)
images could have a significant impact on diagnosing and staging malignant disease and on …

Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins.
Substantial progress has been made toward understanding the function of each protein, and …

Background: frailty is an especially problematic expression of population ageing. International
guidelines recommend routine identification of frailty to provide evidence-based treatment…

Human Immunodeficiency Viruses (HIV-1 and HIV-2) rely upon host-encoded proteins to
facilitate their replication. Here, we combined genome-wide siRNA analyses with interrogation …

There has never been a wholesale way of identifying neurons that are monosynaptically
connected either to some other cell group or, especially, to a single cell. The best available tools…