Neuraminidase inhibitors for preventing and treating influenza in adults and children

…, EA Spencer, IJ Onakpoya, KR Mahtani… - Cochrane database …, 2014 - cochranelibrary.com
Background Neuraminidase inhibitors (NIs) are stockpiled and recommended by public
health agencies for treating and preventing seasonal and pandemic influenza. They are used …

Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA …

KR Mahtani, M Brook, JLE Dean, G Sully… - … and cellular biology, 2001 - Taylor & Francis
Signal transduction pathways regulate gene expression in part by modulating the stability of
specific mRNAs. For example, the mitogen-activated protein kinase (MAPK) p38 pathway …

Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade

M Lasa, KR Mahtani, A Finch, G Brewer… - … and cellular biology, 2000 - Taylor & Francis
A tetracycline-regulated reporter system was used to investigate the regulation of
cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) p38 …

[HTML][HTML] A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

N Hoveyda, C Heneghan, KR Mahtani, R Perera… - BMC …, 2009 - Springer
Background Irritable Bowel Syndrome (IBS) is a common chronic gastrointestinal disorder
and the evidence for efficacy of most drug therapies in the treatment of IBS is weak. A popular …

The 3′ untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR

JLE Dean, R Wait, KR Mahtani, G Sully… - … and cellular biology, 2001 - Taylor & Francis
Posttranscriptional regulation is important for tumor necrosis factor alpha (TNF-α) expression
in monocytes and macrophages, and an AU-rich element (ARE) in the 3′ untranslated …

[HTML][HTML] Why clinical trial outcomes fail to translate into benefits for patients

C Heneghan, B Goldacre, KR Mahtani - Trials, 2017 - Springer
Clinical research should ultimately improve patient care. For this to be possible, trials must
evaluate outcomes that genuinely reflect real-world settings and concerns. However, many …

Reminder packaging for improving adherence to self‐administered long‐term medications

KR Mahtani, CJ Heneghan… - … of systematic reviews, 2011 - cochranelibrary.com
Background Current methods of improving medication adherence for health problems are
mostly complex, labour‐intensive, and not reliably effective. Medication'reminder packaging', …

Global developments in social prescribing

…, M Polley, BC Giurca, S Slade, S Dias, KR Mahtani… - BMJ Global …, 2022 - gh.bmj.com
Social prescribing is an approach that aims to improve health and well-being. It connects
individuals to non-clinical services and supports that address social needs, such as those …

[HTML][HTML] COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time

…, C Marston, A Powell-Smith, C Heneghan, KR Mahtani - Trials, 2019 - Springer
Background Discrepancies between pre-specified and reported outcomes are an important
source of bias in trials. Despite legislation, guidelines and public commitments on correct …

The efficacy of mindfulness-based interventions in primary care: a meta-analytic review

…, E Zabaleta-del-Olmo, KR Mahtani… - The Annals of Family …, 2015 - Annals Family Med
PURPOSE Positive effects have been reported after mindfulness-based interventions (MBIs)
in diverse clinical and nonclinical populations. Primary care is a key health care setting for …