A series of human and animal investigations has suggested that altered expression and
function of the α7-nicotinic cholinergic receptor may be responsible for the auditory sensory …

Schizophrenia can be partially characterized by deficits in sensory processing. Biochemical,
molecular, and genetic studies of one such endophenotype, the P50 auditory-evoked …

Sensory gating abnormalities are an early clinical symptom of schizophrenia, and are
characterized by a decrease in the brain’s normal ability to inhibit the response to unimportant …

Context The α7 nicotinic acetylcholine receptor gene,CHRNA7, is associated with genetic
transmission of schizophrenia and related cognitive and neurophysiological sensory gating …

Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment
polarity gene Dishevelled, were created by gene targeting. Dvl1- deficient mice are viable, …

Objective: Nicotinic acetylcholine receptors are possible therapeutic targets for schizophrenia,
as shown by neurobiological and molecular evidence for deficiencies in expression of α 7 …

Abnormal sensory inhibition is a measurable indicator of a sensory processing deficit which
is observed in schizophrenia, and other disorders, and which may be heritable. This deficit …

Objective Deficient cerebral inhibition is a pathophysiological brain deficit related to poor
sensory gating and attention in schizophrenia and other disorders. Cerebral inhibition …

Current antipsychotic treatments fail to fully address the range of symptoms of schizophrenia,
particularly with respect to social and occupational dysfunctions. Recent work has …

Prenatal stress (PS) impairs memory function; however, it is not clear whether PS-induced
memory deficits are specific to spatial memory, or whether memory is more generally …