A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis
…, M Dewerchin, A Devos, K Tan… - Proceedings of the …, 2004 - National Acad Sciences
Androgens control spermatogenesis, but germ cells themselves do not express a functional
androgen receptor (AR). Androgen regulation is thought to be mediated by Sertoli and …
androgen receptor (AR). Androgen regulation is thought to be mediated by Sertoli and …
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees
OBJECTIVE— Melanocortin-4 receptor (MC4R) deficiency is the most frequent genetic
cause of obesity. However, there is uncertainty regarding the degree of penetrance of this …
cause of obesity. However, there is uncertainty regarding the degree of penetrance of this …
The role of androgens in Sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor
KAL Tan, K De Gendt, N Atanassova, M Walker… - …, 2005 - academic.oup.com
The role of androgens in the proliferation and maturation of Sertoli cells (SC) and the
development of their capacity to support spermatogenesis remains poorly understood. We …
development of their capacity to support spermatogenesis remains poorly understood. We …
Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells
…, I Le Roux, M Corsin-Jimenez, K Tan… - International …, 2000 - academic.oup.com
Signals derived from antigen-presenting cells (APC) influence the functional differentiation
of CD4 + T cells. We report here that Serrate1 (Jagged1), a ligand for the Notch1 receptor, …
of CD4 + T cells. We report here that Serrate1 (Jagged1), a ligand for the Notch1 receptor, …
[HTML][HTML] MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains
A novel Bax-associating protein, named MAP-1 (Modulator of Apoptosis), has been identified
in a yeast two-hybrid screen. MAP-1 contains a BH3-like (BH:Bcl-2 homology) motif and …
in a yeast two-hybrid screen. MAP-1 contains a BH3-like (BH:Bcl-2 homology) motif and …
[BOOK][B] Clean, green and blue: Singapore's journey towards environmental and water sustainability
YS Tan, TJ Lee, K Tan - 2009 - books.google.com
When Singapore became a sovereign state in 1965, the fledgling nation faced very similar
problems as most other developing countries: high unemployment, low standard of living, and …
problems as most other developing countries: high unemployment, low standard of living, and …
The effect of a Sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice
…, K Marchal, P Van Hummelen, KAL Tan… - Molecular …, 2006 - academic.oup.com
To unravel the molecular mechanisms mediating the effects of androgens on spermatogenesis,
testicular gene expression was compared in mice with Sertoli cell-selective androgen …
testicular gene expression was compared in mice with Sertoli cell-selective androgen …
A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children
Objective: Genetic components of energy homeostasis contributing to childhood obesity are
poorly understood. Genome scans were performed to identify chromosomal regions …
poorly understood. Genome scans were performed to identify chromosomal regions …
[HTML][HTML] Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma …
…, RD Haggart, G Miele, G Sellar, KAL Tan… - PloS one, 2013 - journals.plos.org
We present the first comparison of global transcriptional changes in canine and human diffuse
large B-cell lymphoma (DLBCL), with particular reference to the nuclear factor-kappa B (…
large B-cell lymphoma (DLBCL), with particular reference to the nuclear factor-kappa B (…
Antecedents and consequences of home-sharing stays: Evidence from a nationwide household tourism survey
This study aims to understand the demand for home-sharing lodging and whether this
accommodation choice influences guest experiences, in terms of overall trip satisfaction and …
accommodation choice influences guest experiences, in terms of overall trip satisfaction and …