Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found
in 50–70% of malignant melanomas 1 . Pre-clinical studies have demonstrated that the B-…

Background Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that
has reached epidemic proportions in children worldwide and is increasing in prevalence. …

Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these
proteins have been regarded as “undruggable.” We developed a decoy targeting STAT3 and …

The lack of core outcome sets for atopic eczema (AE) is a major obstacle for advancing
evidence-based treatment. The global Harmonising Outcome Measures for Eczema (HOME) …

Background Skin barrier dysfunction precedes eczema development. We tested whether
daily use of emollient in the first year could prevent eczema in high-risk children. Methods We …

Core outcome sets (COSs) are consensus-derived minimum sets of outcomes to be
assessed in a specific situation. COSs are being increasingly developed to limit outcome-reporting …

Objective To determine whether ciclosporin is superior to prednisolone for the treatment of
pyoderma gangrenosum, a painful, ulcerating skin disease with a poor evidence base for …

Background Cellulitis of the leg is a common bacterial infection of the skin and underlying
tissue. We compared prophylactic low-dose penicillin with placebo for the prevention of …

Background Investigators often use global assessments to provide a snapshot of overall
disease severity in dermatologic clinical trials. Although easy to perform, the frequency of use …

Background Pyoderma gangrenosum (PG) is a rare ulcerative skin condition with no current
standardized outcomes or outcome measures. With a rich investigational therapeutic …