2018 marks the 100-year anniversary of the 1918 influenza pandemic, which killed ~50
million people worldwide. The severity of this pandemic resulted from a complex interplay …

Acute respiratory distress syndrome (ARDS) is a fatal complication of influenza infection. In
this Review we provide an integrated model for its pathogenesis. ARDS involves damage to …

Two mini-sequencing methods, FP-TDI (template-directed dye-terminator incorporation with
fluorescence-polarization) and MassArray (matrix assisted laser desorption ionization time …

Numerous viruses use specialized surface molecules called fusogens to enter host cells.
Many of these viruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-…

Efforts are being made worldwide to understand the immune response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus …

Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease
caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on a …

Klebsiella pneumoniae causes significant morbidity and mortality worldwide, particularly
amongst hospitalized individuals. The principle mechanism for pathogenesis in hospital …

Streptococcus pneumoniae (the pneumococcus) kills ~1.6 million people annually. Pneumococcal
infections predominantly manifest as pneumonia, sepsis, meningitis, and otitis media. …

A major cause of respiratory failure during influenza A virus (IAV) infection is damage to the
epithelial–endothelial barrier of the pulmonary alveolus. Damage to this barrier results in …

Influenza A viruses are amongst the most challenging viruses that threaten both human and
animal health. Influenza A viruses are unique in many ways. Firstly, they are unique in the …