Background The efficacy of inhaled corticosteroids in the treatment of chronic obstructive
pulmonary disease (COPD) remains controversial because of a lack of placebo-controlled …

STUDY QUESTION What is the recommended management for women and transgender
men with regards to fertility preservation (FP), based on the best available evidence in the …

Background Variations in intervention rates, without subsequent reductions in adverse
outcomes, can indicate overuse. We studied variations in and associations between commonly …

Background Evidence for the management of chronic obstructive pulmonary disease (COPD)
comes from closely monitored efficacy trials involving groups of patients who were …

The British government is currently considering whether to review the law on information
provision for donor offspring. This paper therefore provides an overview of the current …

This article reports on a systematic review of all (19) English language research reports
published in peer-reviewed journals up to 2011 exploring donor-conceived people’s …

Background Evidence for management of asthma comes from closely monitored efficacy
trials done in highly selected patient groups. There is a need for randomised trials that are …

Donor conception has been practised for many years, initially as a means of bypassing male
fertility problems through the use of donated semen. More recently, semen donation has …

Like any discipline, bioethics is a developing field of academic inquiry; and recent trends in
scholarship have been towards more engagement with empirical research. This ‘empirical …

Background Combination therapy with an inhaled corticosteroid (ICS) and long-acting β 2
agonist (LABA) is recommended for patients with asthma symptomatic on ICS alone. However, …