BACKGROUND: Conducting a pragmatic randomised trial in primary care is often accompanied
by practical problems. Such problems are seldom reported and may constitute useful …

Tractography based on non-invasive diffusion imaging is central to the study of human brain
connectivity. To date, the approach has not been systematically validated in ground truth …

… The admiralty resolution describes the on-site inspection of the Heemskerk epitaph by Willem
van Mathenesse and Dirck Sticke, members of the States-General who were assigned as …

During immune surveillance and inflammation, leukocytes exit the vasculature through
transient openings in the endothelium without causing plasma leakage. However, the exact …

Fiber tractography based on non-invasive diffusion imaging is at the heart of connectivity
studies of the human brain. To date, the approach has not been systematically validated in …

… 12Laboratory of Mathematics in Imaging, Harvard Medical School, Boston, MA 02215,
USA. 13Center for Research in Mathematics, Guanajuato 36023, Mexico. 14PROVIDI Lab …

Background Tuberculous meningitis is often lethal. Early antituberculosis treatment and
adjunctive treatment with glucocorticoids improve survival, but nearly one third of patients with …

Background β-thromboglobulins are derived from the cleavage of the CXC chemokine
platelet basic protein and are released in high concentrations by activated platelets. Platelet-…

Aggregation of platelets via activated integrin α IIb β 3 is a prerequisite for thrombus
formation. Phosphatidylserine-exposing platelets with a key role in the coagulation process …

Objective— ADP is a key platelet agonist in thromboembolism. One of the receptors
involved in ADP-induced platelet activation is the P2Y 12 receptor, which is a target for …